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Peripheral Artery Disease: Diagnosis, Ankle–Brachial Index and Risk Management

…the aorta or arteries supplying the limbs. In adults over 40 years of age, atherosclerosis is the predominant cause. Other mechanisms include thrombosis, embolism, vasculitis…

Unstable Angina: Definition and Contemporary Management

…atherosclerosis or may be the dominant cause of ischaemia. Other mechanisms capable of obstructing coronary arteries include embolism, dissection, coronary arteritis associated with systemic vasculitis…

Leg ulcers — wound debridement and compression therapy

…of other cause As above Severe pain Titrate the pressure up gradually Rheumatoid arthritis with vasculitis Individual assessment Repeat the ABI every three to six…

Other ECG changes in ischemia and infarction

…order to suggest ischemia. Inverted U waves are even more typical of ischemia (but the sensitivity is low). U wave changes always accompany other ischemic…

Acute exacerbation of COPD: quick reference

…and circulation. 2. Give controlled oxygen with a target of 88 to 92 percent until the risk of hypercapnia has been assessed. 3. Take an…

🟠 Ticagrelor (Brilinta, Brilique)

…or a prior heart attack and a high risk of developing an atherothrombotic event. Contraindications Hypersensitivity to the active substance or any excipient. Active bleeding…

Familial and Genetic Screening in Premature Cardiovascular Disease

…dominant transmission, in which an affected heterozygous individual has a 50% risk of transmitting the relevant variant to each child. However, other inheritance patterns, de…

LDL Cholesterol Targets Across Cardiovascular Risk Categories

…combined dyslipidaemia, non HDL C is particularly relevant because it captures triglyceride rich lipoproteins in addition to LDL and other apoB containing particles. Cardiovascular risk…

Myocardial Ischemia & infarction: Cellular changes, ECG and symptoms

…the supply and demand of ATP; increased cardiac workload results in increased ATP production and vice versa. Importantly, cardiac myocytes require aerobic metabolism (oxygen) to…

Acute coronary syndrome: quick reference for loading doses and time targets

…than 12 hours, immediate fibrinolysis is recommended in the absence of contraindications, followed by direct transfer to a PCI centre [1,5]. Situation Practical target…

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