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Colchicine and Anti-inflammatory Therapy in Coronary Disease

…C reactive protein, has been a major therapeutic target. This concept is clinically relevant because cardiovascular risk may persist despite appropriate lipid lowering and other…

Bempedoic Acid: Evidence and Clinical Use

…C, non high density lipoprotein cholesterol, apolipoprotein B and high sensitivity C reactive protein (hsCRP). Bempedoic acid also activates adenosine monophosphate activated protein kinase, which…

Cardiovascular effects of COVID-19 (Coronavirus Disease 2019)

…The vast majority of infections with COVID 19 result in mild disease, with symptoms similar to seasonal flu (influenza) and other viral respiratory infections. However…

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…within the subendothelial space, LDL C particles undergo oxidative modification by reactive oxygen species (ROS) and enzymes such as myeloperoxidase and lipoxygenase. Oxidized LDL (oxLDL…

Assessment of the pupillary reflex in cardiac arrest

…of spontaneous circulation (ROSC). A brisk, reactive pupil generally indicates an intact brainstem and adequate cerebral perfusion, whereas fixed, dilated pupils can signal severe global…

Familial and Genetic Screening in Premature Cardiovascular Disease

…Familial and genetic screening in cardiovascular medicine is the systematic assessment of relatives and other individuals who may carry an inherited predisposition to cardiovascular disease…

Dix–Hallpike test and Epley manoeuvre

…drugs . The diagnosis rests on the history, a positive Dix–Hallpike test and the absence of other neurological findings. The treatment is a repositioning manoeuvre…

Aspirin in Primary Prevention: Current Recommendations

…only one pathway of platelet activation, its antiplatelet effect is relatively limited compared with agents that inhibit other platelet pathways. The distinction between primary and…

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Multivessel Coronary Artery Disease

…and treatment goals Diabetes, left ventricular function and other comorbidities Surgical risk and contraindications to prolonged dual antiplatelet therapy Patient preferences, local expertise and operator…

Myocardial Ischemia & infarction: Cellular changes, ECG and symptoms

…and infarction Myocardial ischemia: cellular changes, ECG signs and development of infarction Like all other cells in the human body, cardiac myocytes use ATP (adenosine…

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