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Primary Aldosteronism: Screening and Management

Cardiology Endocrinology & metabolism Definition and pathophysiology Primary aldosteronism (PA), also termed primary hyperaldosteronism or Conn syndrome, comprises disorders in which aldosterone secretion is inappropriately increased…

Secondary Hypertension: When and How to Investigate

…hypokalaemia. Endocrine disorders account for many secondary forms. Primary hyperaldosteronism is identified as the most frequent cause, comprising approximately 20–25% of secondary hypertension cases…

Aspirin in Primary Prevention: Current Recommendations

…limited compared with agents that inhibit other platelet pathways. The distinction between primary and secondary prevention is fundamental: Primary prevention refers to individuals without established…

Dix–Hallpike test and Epley manoeuvre

Procedurer Benign paroxysmal positional vertigo is the commonest cause of vertigo in primary care and one of the few diagnoses that can be cured on…

Myocardial Ischemia & infarction: Cellular changes, ECG and symptoms

…ECG signs and development of infarction Like all other cells in the human body, cardiac myocytes use ATP (adenosine triphosphate) as the primary energy source…

LDL Cholesterol Targets Across Cardiovascular Risk Categories

…captures triglyceride rich lipoproteins in addition to LDL and other apoB containing particles. Cardiovascular risk categories Primary prevention For adults aged 40–75 years without…

Smoking Cessation: Pharmacotherapy and Cardiovascular Benefit

…with avoidance of second hand smoke and, where possible, other inhaled nicotine products. In cardiovascular medicine, the objective is not merely to reduce cigarette consumption…

Approach to patients with chest pain: differential diagnoses, management & ECG

…one of the most common symptoms in the emergency department, as well as in primary health care. The cause (etiology) of chest pain varies according…

Acute coronary syndrome: quick reference for loading doses and time targets

…dangerous differential diagnoses [1,2]. STEMI and other ECG patterns suggesting acute coronary occlusion are time dependent conditions. The decision on immediate reperfusion is based…

Liver parameters

…tumour, primary biliary cholangitis, drugs Mixed Both raised Drug induced liver injury is the commonest cause Isolated bilirubin Unconjugated, the others normal Gilbert's syndrome…

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