…is an oral, small molecule lipid lowering agent used to reduce low density lipoprotein cholesterol (LDL C), particularly when statins cannot be tolerated or when…

…indication for oral anticoagulation (OAC). Clinical context and treatment objectives DAPT is used in two principal settings: After ACS , whether managed medically or with revascularization…

…1 to 2 hours. Oral onset is delayed, typically requiring 2 to 3 days, and often 1 to 3 weeks or occasionally longer; loading doses…

…as MDMA (ecstasy) or amphetamines. In either scenario, there is sustained muscle activation, leading to marked heat generation, acidosis, and the subsequent development of hyperkalemia…

…be absent or nonspecific Treatment setting Usually hospital based, often ICU Usually outpatient Initial treatment Carefully titrated intravenous therapy when indicated Oral treatment and prompt…

…acute kidney injury, microangiopathic haemolysis, and severe pre eclampsia or eclampsia. The blood pressure is often at least 180/120 mmHg, but no absolute threshold…

…a contraindication, an indication for oral anticoagulation, or an excessive risk of bleeding. The duration and intensity may be modified according to: bleeding risk; ischemic…

…oral agents initially developed for glucose lowering in type 2 diabetes mellitus (T2DM). The principal drugs identified in the source material are canagliflozin, dapagliflozin and…

…injecting into it, and expect the procedure to hurt even so. Offer nitrous oxide, oral or intravenous analgesia, or procedural sedation in advance. Inadequate analgesia…

…is incomplete: reduce the calculated equianalgesic dose by 25–50 per cent and titrate. At a high dose, in old age or in renal failure…