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The Fourth Universal Definition of Myocardial Infarction: Types 1–5

…sarcolemma. These changes may appear within 10–15 minutes of ischaemia. Mitochondrial abnormalities can occur even earlier after coronary occlusion and progress over time. Experimentally…

Levosimendan (Simdax, Simendan) in acute heart failure

…without increasing myocardial oxygen consumption. The inotropic effect of levosimendan is not affected by the concurrent use of beta blockers. The vasodilating effect reduces preload…

Relaxation of the left ventricle

…include age, afterload, myocardial synchronization and intracellular processes ( e.g intracellular calcium signaling, the sodium–potassium pump, mitochondrial function, actin myosin interactions, etc. ). Afterload Afterload…

Incretins in Cardiometabolic Medicine: Leveraging GLP-1, GIP, and Glucagon Receptor Agonism for Cardiovascular Risk Reduction

…Clinical guidelines now emphasize that a BMI within the conventional "normal" range (up to 25 kg/m²) does not necessarily equate to optimal cardiovascular health…

Dilated Cardiomyopathy (DCM): Definition, Types, Diagnostics & Treatment

…is currently the most common indication for heart transplantation. Echocardiography can not distinguish different types of dilated cardiomyopathy. Other causes of ventricular dilation ( e.g…

The 3-phase model of sudden cardiac arrest

…However, current guidelines do not consider this fact (beyond the recommendation to defibrillate immediately if cardiac arrest is witnessed and the rhythm is shockable). This…

Physics of myocardial perfusion imaging (SPECT, PET): Radiotracers, perfusion, blood flow and viability

…allowing high doses for better image quality. this tracer diffuses passively into cardiomyocytes, binding to mitochondria, with minimal redistribution. Thallium 201: This is a potassium…

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