Cardiology Pharmacology & dosing Definition and therapeutic rationale Inclisiran is a liver directed small interfering RNA (siRNA) designed to reduce production of proprotein convertase subtilisin/kexin…

…of chemotherapy, but the timing varies considerably between regimens. Neutropenia can also be caused by haematological malignancy, stem cell transplantation, immunosuppressive drugs, radiotherapy, bone marrow…

…History of stroke or transient ischemic attack (TIA). Severely impaired liver function classified as Child Pugh Class C. Dosage Adults Initial dose : A single loading…

…hyperinsulinaemia and, with progression, hyperglycaemia and pancreatic β cell dysfunction. These abnormalities initiate self perpetuating metabolic and inflammatory pathways that injure the vasculature, heart and…

…a guidewire, a dilator and a 5–8 F pigtail catheter , plus a drainage bag. Sample tubes for cell count, chemistry, culture and cytology, and…

…Amyloidosis: This form arises from the misfolding of transthyretin, a protein produced primarily in the liver [10]. ATTR is subclassified based on the TTR gene…

…the reductions in hard cardiovascular outcomes (MI, stroke) and metabolic liver disease involve significant weight independent pathways. 15 Metabolic Reprogramming and Vascular Health GLP 1…

…pulmonary vascular disease. This state is termed unclassified PH. Potential explanations include congenital heart disease, liver disease, airway or lung disease, and hyperthyroidism; follow up…

Infektionssjukdomar Akutsjukvård Lathundar Purpose and scope A quick reference for the doctor on call faced with suspected sepsis in adults: rapid recognition, microbiological sampling, empirical…

…grouping and cross matching. Order red cells early with ongoing major bleeding 4 Tests: haemoglobin, platelet count, INR, APTT, creatinine, electrolytes, liver function tests, albumin…