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🟠 Ticagrelor (Brilinta, Brilique)

…ritonavir, and atazanavir) can lead to a significant increase in exposure to ticagrelor. Dosage: Acute Coronary Syndromes Treatment with Ticagrelor should start with a loading…

Exercise Electrocardiographic Testing: Indications, Limitations and Interpretation

…pressure, particularly when accompanied by evidence of ischaemia, may indicate exercise induced global left ventricular dysfunction. Exercise testing also provides physiological information independent of ischaemia…

Heart Failure With Preserved Ejection Fraction: Diagnosis and Treatment

…occur because elevated left sided filling pressures are transmitted to the pulmonary circulation. Persistent pulmonary vascular disease can lead to right ventricular strain and dysfunction…

Aortic regurgitation

…the left ventricle dilates, which induces irreversible cellular and extracellular processes that ultimately lead to heart failure. This initially results in greater diastolic volume and…

Inotropes and vasopressors: doses, indications, contraindications and effects

…acute or chronic. Bradycardia (second line option). 10.0–20.0 μg/kg/min ++++ ++++ ++ +++++ High dose dopamine additionally induces α1 stimulation and thereby vasoconstriction…

Heart Failure with Preserved Ejection Fraction (HFpEF)

…hypothesis, initially proposed by Paulus and Tschöpe, is the "systemic microvascular inflammation paradigm" [9] . In this model, systemic comorbidities (obesity, hypertension, diabetes) induce a chronic…

Tachycardia induced cardiomyopathy

…Yokokawa et al). Tachycardia induced cardiomyopathy is presumably the main cause of left ventricular dysfunction among patients with atrial fibrillation and other supraventricular tachyarrhythmias. Moreover…

Dilated Cardiomyopathy (DCM): Definition, Types, Diagnostics & Treatment

…left main coronary artery (LAD) or 2 epicardial coronary arteries (Felker et al). Left ventricular dilation entails a markedly elevated risk of ventricular tachycardia and…

Vasospastic (Prinzmetal) Angina: Provocation Testing and Treatment

…arteries. Epicardial spasm produces a reversible functional occlusion and usually causes transmural ischaemia. The resulting abnormalities in left ventricular function may lead to myocardial infarction…

Exercise stress test on cycle ergometer

…Relative: Condition Comment : : Left main stenosis Known — perform the test only on a clear indication and with full preparedness Moderate to severe aortic stenosis without…

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