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Acute Limb Ischaemia: Recognition and Urgent Management

…Capillary refill is delayed, and venous filling may be reduced. Other possible findings include muscle stiffening and loss of deep tendon reflexes. Pulses are absent…

Statin Intolerance and Statin-Associated Muscle Symptoms

…myositis with muscle inflammation and elevated CK. Rhabdomyolysis is a rare, severe form of muscle injury. The biological basis of many reported muscle symptoms remains…

Reduction of dislocations

…longer a joint remains dislocated, the harder the reduction becomes and the greater the risk of chondral and neurovascular injury. Aim for reduction within a…

Cardiac troponin I (TnI) and T (TnT): Interpretation and evaluation in acute coronary syndromes

…are cardiac specific isoforms of troponin and these are abbreviated cTnI, cTnT, and cTnC. The isoforms cTnI and cTnT are specific to cardiac muscle cells…

Myocardial Injury Versus Infarction: Interpreting Troponin Elevation

…are components of the myocardial contractile apparatus and are expressed predominantly in cardiac muscle. Troponin I is highly specific for myocardial injury. Interpretation of troponin…

Type 2 Myocardial Infarction: Mechanisms and Management

…ischaemic myocardial injury may coexist, and certain disease entities can span both categories; for example, acute heart failure may occur in the context of acute…

ST-Elevation Myocardial Infarction: Diagnosis and Electrocardiographic Criteria

…muscle cells, leading to a white, platelet rich thrombus. Myocardial vulnerability, largely driven by coronary microvascular dysfunction, also contributes to the extension and severity of…

Acute kidney injury: quick reference for management

…marker of function and may rise only after a substantial fall in glomerular filtration. The value is affected by muscle mass, nutrition, drugs and fluid…

Primary Aldosteronism: Screening and Management

…relatives of patients with PA Patients with hypokalaemia may develop weakness, muscle cramps or, in severe cases, periodic paralysis. Nevertheless, many patients are normokalaemic and…

Peripheral Artery Disease: Diagnosis, Ankle–Brachial Index and Risk Management

…stress and intimal injury promote atherosclerosis. The principal anatomical distributions are: Abdominal aorta and iliac arteries, involved in approximately 30% of symptomatic patients. Femoral and…

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