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Acute Limb Ischaemia: Recognition and Urgent Management

…Capillary refill is delayed, and venous filling may be reduced. Other possible findings include muscle stiffening and loss of deep tendon reflexes. Pulses are absent…

Statin Intolerance and Statin-Associated Muscle Symptoms

…myositis with muscle inflammation and elevated CK. Rhabdomyolysis is a rare, severe form of muscle injury. The biological basis of many reported muscle symptoms remains…

Reduction of dislocations

…to a prosthesis) — a high risk of avascular necrosis of the femoral head and of vascular injury; always an orthopaedic surgeon, and usually general anaesthesia…

Cardiac troponin I (TnI) and T (TnT): Interpretation and evaluation in acute coronary syndromes

…cardiac muscle cells. Cardiac troponin levels are extremely low in healthy subjects; the 99 th percentile is less than a few nanograms per liter of…

Myocardial Injury Versus Infarction: Interpreting Troponin Elevation

…are components of the myocardial contractile apparatus and are expressed predominantly in cardiac muscle. Troponin I is highly specific for myocardial injury. Interpretation of troponin…

Type 2 Myocardial Infarction: Mechanisms and Management

…cTn) values in the setting of acute or chronic heart failure are often better categorised as myocardial injury. Clinical Presentation and Symptoms Patients with Type…

ST-Elevation Myocardial Infarction: Diagnosis and Electrocardiographic Criteria

…muscle cells, leading to a white, platelet rich thrombus. Myocardial vulnerability, largely driven by coronary microvascular dysfunction, also contributes to the extension and severity of…

Acute kidney injury: quick reference for management

…marker of function and may rise only after a substantial fall in glomerular filtration. The value is affected by muscle mass, nutrition, drugs and fluid…

Primary Aldosteronism: Screening and Management

…relatives of patients with PA Patients with hypokalaemia may develop weakness, muscle cramps or, in severe cases, periodic paralysis. Nevertheless, many patients are normokalaemic and…

Peripheral Artery Disease: Diagnosis, Ankle–Brachial Index and Risk Management

…stress and intimal injury promote atherosclerosis. The principal anatomical distributions are: Abdominal aorta and iliac arteries, involved in approximately 30% of symptomatic patients. Femoral and…

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