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Injection technique — intramuscular, subcutaneous and intradermal

…hypersensitivity to the preparation. Intramuscular injection in marked coagulopathy or thrombocytopenia (< 50 ×10⁹/L) — choose the subcutaneous route if possible, otherwise give IM with…

Cardiovascular Risk in Inflammatory and Autoimmune Disease

Cardiology Clinical medicine Definition and scope Inflammatory and autoimmune diseases are immune mediated inflammatory diseases (IMIDs) that include rheumatoid arthritis (RA), psoriatic arthritis, spondyloarthropathies, systemic…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…of the arterial wall in which lipid accumulation, vascular cell dysfunction, immune cell recruitment, extracellular matrix remodelling, and thrombosis interact to produce focal arterial lesions…

Colchicine and Anti-inflammatory Therapy in Coronary Disease

…and acute coronary syndromes have important inflammatory components. Inflammation contributes to atherothrombosis through activation of innate immune pathways, cytokine signalling and recruitment of inflammatory cells…

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…debris, modern vascular biology has redefined atherosclerosis as a dynamic, immune mediated fibroproliferative response to endothelial injury [2] . The process initiates with endothelial dysfunction, a…

Post-Infarction Pericarditis and Dressler Syndrome

…AMI, although descriptions of the syndrome include a broader interval of approximately 1–8 weeks. The pathogenesis is presumed to be immune mediated. Pericardial injury…

Statin Intolerance and Statin-Associated Muscle Symptoms

…plaque stability, thrombogenic responses and immune activity. Statin intolerance refers to adverse effects attributed to statin treatment that improve or resolve after reducing the dose…

Endocarditis: definitions, causes, diagnosis, echocardiography & treatment

…Infections are difficult to heal because the heart valves are not vascularized and therefore it is difficult for the immune system to reach the bacteria…

Heart Failure with Reduced Ejection Fraction (HFrEF)

…and infiltrative causes are increasingly recognized. The burgeoning field of cardio oncology has highlighted the cardiotoxic effects of anthracyclines, HER2 inhibitors (trastuzumab), and immune check

Introduction to Coronary Artery Disease (Ischemic Heart Disease)

…atherosclerosis is a disease in which the immune system elicits an active inflammation within the artery wall and lipids (particularly LDL cholesterol) plays a key…

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