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Cardiovascular Risk in Inflammatory and Autoimmune Disease

Cardiology Clinical medicine Definition and scope Inflammatory and autoimmune diseases are immune mediated inflammatory diseases (IMIDs) that include rheumatoid arthritis (RA), psoriatic arthritis, spondyloarthropathies, systemic…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…of the arterial wall in which lipid accumulation, vascular cell dysfunction, immune cell recruitment, extracellular matrix remodelling, and thrombosis interact to produce focal arterial lesions…

Colchicine and Anti-inflammatory Therapy in Coronary Disease

…infarction Pharmacology & dosing Definition and pathophysiology Atherosclerosis and acute coronary syndromes have important inflammatory components. Inflammation contributes to atherothrombosis through activation of innate immune pathways…

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…progressive, and highly complex lipid driven inflammatory disease of the arterial intima that serves as the fundamental pathophysiological substrate for acute coronary syndromes (ACS), including…

Post-Infarction Pericarditis and Dressler Syndrome

…after AMI, although descriptions of the syndrome include a broader interval of approximately 1–8 weeks. The pathogenesis is presumed to be immune mediated. Pericardial…

Statin Intolerance and Statin-Associated Muscle Symptoms

…plaque stability, thrombogenic responses and immune activity. Statin intolerance refers to adverse effects attributed to statin treatment that improve or resolve after reducing the dose…

Endocarditis: definitions, causes, diagnosis, echocardiography & treatment

…Infections are difficult to heal because the heart valves are not vascularized and therefore it is difficult for the immune system to reach the bacteria…

Injection technique — intramuscular, subcutaneous and intradermal

…muscle. With a 25 mm needle the dose ends up subcutaneously, which gives a poorer immune response and more local reaction. Procedure Intramuscular — deltoid 1…

Heart Failure with Reduced Ejection Fraction (HFrEF)

Cardiology Definition and terminology Heart failure (HF) is a complex clinical syndrome characterized by symptoms and signs resulting from structural or functional impairment of ventricular…

Introduction to Coronary Artery Disease (Ischemic Heart Disease)

…atherosclerosis is a disease in which the immune system elicits an active inflammation within the artery wall and lipids (particularly LDL cholesterol) plays a key…

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