Articles & courses

Articles
Colchicine and Anti-inflammatory Therapy in Coronary Disease

…activation of innate immune pathways, cytokine signalling and recruitment of inflammatory cells to vascular lesions. The interleukin 1β pathway, with downstream effects involving interleukin…

Statin Intolerance and Statin-Associated Muscle Symptoms

…apoB 100 containing lipoproteins and exert effects beyond LDL C reduction, including modulation of inflammation, oxidative stress, endothelial function, plaque stability, thrombogenic responses and immune…

Injection technique — intramuscular, subcutaneous and intradermal

…mm needle the dose ends up subcutaneously, which gives a poorer immune response and more local reaction. Procedure Intramuscular — deltoid 1. Expose the whole shoulder…

Heart Failure with Reduced Ejection Fraction (HFrEF)

…and infiltrative causes are increasingly recognized. The burgeoning field of cardio oncology has highlighted the cardiotoxic effects of anthracyclines, HER2 inhibitors (trastuzumab), and immune check

Cardiovascular Risk in Inflammatory and Autoimmune Disease

…directly attributable to CVD. Excess mortality becomes apparent approximately 7–10 years after diagnosis and is associated with persistent disease activity, rheumatoid factor and anti…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…is a chronic, inflammatory disease of the arterial wall in which lipid accumulation, vascular cell dysfunction, immune cell recruitment, extracellular matrix remodelling, and thrombosis interact…

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…compromises the endothelial barrier, upregulating the expression of vascular cell adhesion molecule 1 (VCAM 1) and intercellular adhesion molecule 1 (ICAM 1), and increasing the…

Post-Infarction Pericarditis and Dressler Syndrome

…after AMI, although descriptions of the syndrome include a broader interval of approximately 1–8 weeks. The pathogenesis is presumed to be immune mediated. Pericardial…

Endocarditis: definitions, causes, diagnosis, echocardiography & treatment

…Infections are difficult to heal because the heart valves are not vascularized and therefore it is difficult for the immune system to reach the bacteria…

Introduction to Coronary Artery Disease (Ischemic Heart Disease)

…in these regions. Mortality rates and case fatality in coronary artery disease peaked in the 1970s and have declined steadily ever since. The marked decline…

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