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Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…extracellular matrix remodelling, and thrombosis interact to produce focal arterial lesions. Although epicardial coronary arteries are a major site of disease, atherosclerosis is systemic and…

Acute vertigo: quick reference for HINTS and differential diagnosis

…but posterior circulation stroke is the most important dangerous differential diagnosis. Clear focal neurological findings are absent in roughly half of patients with a central…

Lumbar puncture

…a reduced level of consciousness, focal neurological signs or seizures — because the delay costs more than the scan contributes. Only clinical signs of herniation halt…

Acute Aortic Syndromes: Intramural Haematoma and Penetrating Atherosclerotic Ulcer

…subclavian artery. Penetrating atherosclerotic ulcer PAU is focal ulceration of an atherosclerotic plaque that penetrates through the internal elastic lamina into the media. The lesion…

Atrial Flutter: Mechanisms, ECG Recognition and Management

…posterior to the superior vena cava. A critical area of slow conduction is consistently located in the posterolateral to posteromedial inferior region of the right…

Carotid Artery Disease: Screening, Medical Therapy and Revascularisation

…stenosis have no focal neurological symptoms. Asymptomatic disease may be discovered during targeted duplex ultrasound (DUS), pre operative assessment, or evaluation of other atherosclerotic disease…

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Multivessel Coronary Artery Disease

…atherosclerotic process. Their clinical effects therefore occur within the broader framework of guideline directed medical therapy and secondary prevention. PCI treats focal stenotic segments, whereas…

Acute exacerbation of COPD: quick reference

…Key messages Two things set the COPD exacerbation apart from many other causes of acute dyspnoea: oxygen must be titrated cautiously and the blood gas…

Alcohol withdrawal and delirium tremens: quick reference

…90 percent of withdrawal seizures occur within 48 hours. Seizures later than this, focal seizures or status epilepticus should raise strong suspicion of another or…

Hypertensive crisis: quick reference for acute blood pressure lowering

…and stabilise the patient Immediate assessment 1. Assess airway, breathing, circulation and level of consciousness. 2. Attach ECG, pulse oximetry and repeated blood pressure measurement…

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