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Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…cell recruitment, extracellular matrix remodelling, and thrombosis interact to produce focal arterial lesions. Although epicardial coronary arteries are a major site of disease, atherosclerosis is…

Acute vertigo: quick reference for HINTS and differential diagnosis

…most important dangerous differential diagnosis. Clear focal neurological findings are absent in roughly half of patients with a central cause. A normal routine neurological examination…

Lumbar puncture

…which needle is chosen, and that the tubes go to the right place. In suspected bacterial meningitis it is the time to antibiotics that saves…

Acute Aortic Syndromes: Intramural Haematoma and Penetrating Atherosclerotic Ulcer

…subclavian artery. Penetrating atherosclerotic ulcer PAU is focal ulceration of an atherosclerotic plaque that penetrates through the internal elastic lamina into the media. The lesion…

Atrial Flutter: Mechanisms, ECG Recognition and Management

…Conversely, certain macroreentrant atrial tachycardias (MRATs) that traverse protected anatomical areas may display a focal atrial tachycardia pattern on the ECG, characterized by discrete P…

Carotid Artery Disease: Screening, Medical Therapy and Revascularisation

…two vascular beds. Carotid disease therefore commonly coexists with coronary artery disease (CAD), peripheral artery disease (PAD), and other manifestations of systemic atherosclerosis. The principal…

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Multivessel Coronary Artery Disease

…left ventricular dysfunction, peripheral vascular disease and other manifestations of diffuse atherosclerosis. Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are revascularization procedures…

Acute exacerbation of COPD: quick reference

…pain, haemoptysis, syncope and palpitations. Orthopnoea, weight gain and peripheral oedema. Previous hypercapnia, NIV or invasive ventilation. Home oxygen and the patient's usual saturation…

Alcohol withdrawal and delirium tremens: quick reference

…Seizures later than this, focal seizures or status epilepticus should raise strong suspicion of another or an additional cause [1]. Delirium tremens most often begins…

Hypertensive crisis: quick reference for acute blood pressure lowering

…blood pressure measurement when a hypertensive emergency is suspected. 3. Insert a peripheral venous cannula. 4. Measure the blood pressure in both arms at the…

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