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Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…cell recruitment, extracellular matrix remodelling, and thrombosis interact to produce focal arterial lesions. Although epicardial coronary arteries are a major site of disease, atherosclerosis is…

Acute vertigo: quick reference for HINTS and differential diagnosis

…most important dangerous differential diagnosis. Clear focal neurological findings are absent in roughly half of patients with a central cause. A normal routine neurological examination…

Lumbar puncture

…known malignancy, immunosuppression, papilloedema or new focal neurological signs — CT is performed first. Preparation and equipment Informed consent, coagulation status and an up to date…

Acute Aortic Syndromes: Intramural Haematoma and Penetrating Atherosclerotic Ulcer

…IMH: involves the descending aorta distal to the left subclavian artery. Penetrating atherosclerotic ulcer PAU is focal ulceration of an atherosclerotic plaque that penetrates through…

Atrial Flutter: Mechanisms, ECG Recognition and Management

…septum. The left atrium is activated passively. The upper boundary of this circuit may be located either anterior or posterior to the superior vena cava…

Carotid Artery Disease: Screening, Medical Therapy and Revascularisation

…carotid stenosis have no focal neurological symptoms. Asymptomatic disease may be discovered during targeted duplex ultrasound (DUS), pre operative assessment, or evaluation of other atherosclerotic…

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Multivessel Coronary Artery Disease

…left ventricular function and other comorbidities Surgical risk and contraindications to prolonged dual antiplatelet therapy Patient preferences, local expertise and operator or institutional experience Assessment…

Acute exacerbation of COPD: quick reference

…with raised pCO₂ Acute or acute on chronic hypercapnic respiratory failure Rapidly falling pH An urgent ventilatory problem Focal chest pain or unilaterally reduced breath…

Alcohol withdrawal and delirium tremens: quick reference

…illness or after prolonged very high intake More than 90 percent of withdrawal seizures occur within 48 hours. Seizures later than this, focal seizures or…

Hypertensive crisis: quick reference for acute blood pressure lowering

…4]. Step 2: look systematically for acute organ damage Organ or condition Findings to look for Initial investigation : : : CNS Confusion, reduced consciousness, visual disturbance, foca

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