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Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…cell recruitment, extracellular matrix remodelling, and thrombosis interact to produce focal arterial lesions. Although epicardial coronary arteries are a major site of disease, atherosclerosis is…

Preeclampsia and Hypertensive Pregnancy Disorders as Future Cardiovascular Risk

…Collectively, they affect approximately 5–15% of pregnancies worldwide and are major contributors to maternal, fetal, and neonatal morbidity and mortality. Their incidence has increased…

Acute vertigo: quick reference for HINTS and differential diagnosis

…how long an attack lasts, and whether anything actually triggers it [1,2]. The single most important practical rule is: Continuous acute dizziness with spontaneous…

Lumbar puncture

…with a reduced level of consciousness, focal neurological signs or seizures — because the delay costs more than the scan contributes. Only clinical signs of herniation…

Warfarin therapy

…option. Contraindications Ongoing clinically significant bleeding. Pregnancy in the first trimester and close to delivery (embryopathy and fetal bleeding respectively). Marked liver failure with coagulopathy…

Acute Aortic Syndromes: Intramural Haematoma and Penetrating Atherosclerotic Ulcer

…subclavian artery. Penetrating atherosclerotic ulcer PAU is focal ulceration of an atherosclerotic plaque that penetrates through the internal elastic lamina into the media. The lesion…

Atrial Flutter: Mechanisms, ECG Recognition and Management

…Conversely, certain macroreentrant atrial tachycardias (MRATs) that traverse protected anatomical areas may display a focal atrial tachycardia pattern on the ECG, characterized by discrete P…

Carotid Artery Disease: Screening, Medical Therapy and Revascularisation

…the general population, the prevalence of asymptomatic carotid stenosis of at least 70% is low, reported as 0–3.1%. In contrast, within selected high…

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Multivessel Coronary Artery Disease

…within the broader framework of guideline directed medical therapy and secondary prevention. PCI treats focal stenotic segments, whereas CABG provides a bypass beyond diseased segments…

Acute exacerbation of COPD: quick reference

…viral infection, bacterial infection and air pollution, but often no definite trigger can be identified [1,2]. Ask specifically about: Onset and time course. Increased…

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