…disease (CAD), atherosclerosis, heart failure (HF), atrial fibrillation and cardiovascular events. In clinical practice, obesity is conventionally defined by a body mass index (BMI) of…

…Low body mass index Asian ancestry Previous muscle disease or a personal or family history of muscle disorders Acute infection Renal or hepatic impairment Hypothyroidism…

…disease typically results in thickening of the leaflets and may coexist with mitral stenosis. Idiopathic degeneration (Barlow's disease), degeneration associated with connective tissue disorders…

…age in the patient or family Hypertensive first degree relatives of patients with PA Patients with hypokalaemia may develop weakness, muscle cramps or, in severe…

…Patients with left ventricular hypertrophy may instead display normalization of secondary T wave inversions (lead V5, V6, aVL, I). ECG in moderate hyperkalaemia Previously mentioned…

…Addison's disease, renal insufficiency, therapeutic interventions with tamoxifen or lithium, thiazide administration, and over supplementation of calcium and vitamin D. ECG in hypercalcemia Typical…

…entrapment, cystic adventitial disease and trauma. Atherosclerotic PAD is a manifestation of systemic arterial disease rather than an isolated disorder of the lower limbs. Patients…

Cardiology Myocardial ischemia and infarction Definition and pathophysiology Atherosclerosis is a chronic, inflammatory disease of the arterial wall in which lipid accumulation, vascular cell dysfunction…

…without acute elevations in cardiac troponin concentrations. Based on the presenting electrocardiogram (ECG) and the presence of troponin elevation, ACS are classified into unstable angina…

…complications. Seizures in a patient with preeclampsia indicate eclampsia. Postpartum disease is clinically important. Hypertension is most frequent in women who had antenatal hypertensive disorders…

…with the electronics in the pulse generator or dislodgement or fracture of the leads. External causes are less common and include electrolyte disorders, metabolic disorders…

…4b and 4c fulfil the criteria for type 1 MI because they represent coronary atherothrombotic events in the setting of a stent thrombosis or restenosis…

…pO₂, A–a gradient or PaO₂/FiO₂ Arterial blood gas COHb or MetHb Arterial or venous sample with co oximetry Follow up of pH in…

…left lateral decubitus position. This affects images obtained in apical windows (refer to Standard Transthoracic Echocardiogram: Complete Imaging Protocol). Nevertheless, there are obvious benefits of…

…is an antiandrogen used in the treatment of prostate cancer. PubMed search Abiraterone ) DrugBank search Abiraterone Aceprometazine None Classified as QT prolonging drug in DrugBank…

…by numerous local and systemic disorders. Accumulation of fluid in the pericardial space may lead to increased intrapericardial pressure, which in turn affects ventricular relaxation…

…component of the overall burden of atherosclerotic cardiovascular disease. SCORE2 is intended principally for adults aged 40–69 years, whereas SCORE2 OP is used in…

…and hyperkalemia. When bradycardia occurs in the context of inflammatory heart disease, it often reflects myocardial pathology that may also reduce myocardial contractility and cause…

…of cardiovascular disease. The biological differences between females and males arise partly from the chromosomal distinction between XX and XY individuals and are reflected in…

…Prophylaxis against recurrence of cerebrovascular disease: 75–80 mg tablet once daily. Warnings and precautions Use Aspirin with caution in the following cases: Concurrent anticoagulant…

…prediction. Familial clustering may also reflect shared environmental or behavioural factors rather than a single gene disorder. This distinction is important in premature coronary disease…

…the high risk of ventricular arrhythmias is due to the vulnerability caused by marked local differences in repolarization. This article is part of the comprehensive…

…is not regarded as a discrete disease; rather, it is an indicator of increased cardiovascular risk and a setting in which secondary hypertension is relatively…

…highly heterogeneous group of disorders. Idiopathic dilated cardiomyopathy (DCM) is frequently diagnosed when ischemic, valvular, and hypertensive causes are excluded. However, advances in molecular diagnostics…

…arrhythmias were observed in the fifth decade of life in several family members. Imaging studies did not reveal structural cardiac abnormalities, nor coronary artery disease…

…fold greater prevalence of asymptomatic atherosclerotic cardiovascular disease (ASCVD) than the general population. The evidence for premature atherosclerosis is particularly strong in RA and SLE…

…disorder caused by separation within the coronary arterial wall, usually through formation of an intramural haematoma that compresses the true lumen. The resulting reduction in…

…secondary. Primary and secondary ST T changes Primary ST T changes are caused by abnormal repolarization . This is seen in ischemia, electrolyte disorders (calcium, potassium)…

…disease. Less frequently, it may also present in individuals without identifiable cardiac disease. Contributing factors include pulmonary disorders, particularly obstructive pulmonary disease, the use of…

…and chaotic ventricular depolarizations, rendering the left ventricle incapable of generating effective contractions. This results in circulatory collapse, loss of consciousness, and sudden cardiac arrest…

…effect of drugs, hypoxia, myocarditis and electrolyte disorders. Because the rate (60–100 beats per minute) is on a par with the rate in sinus…

…valvular heart disease. In these populations, one of the strongest predictors of sudden cardiac death is left ventricular function. Individuals with reduced left ventricular function…

…investigations. The emergency differential also reflects distinct mechanisms of acute cardiopulmonary disease: Pulmonary embolism and spontaneous pneumothorax may produce abrupt chest pain and respiratory distress…

…particularly for intermediate non left main coronary stenoses. Myocardial ischaemia may occur despite the absence of significant epicardial obstruction. In patients with anginal symptoms and…

…metabolic abnormalities; and abnormal pain perception in patients without demonstrable ischaemia. The absence of obstructive disease therefore does not establish a benign diagnosis. ANOCA/INOCA…

…generally defined as the absence of a stenosis of 50% or more in any potential infarct related artery. MINOCA is not a definitive disease diagnosis…

…those in Brugada syndrome. This disorder is easy to diagnose with a simple blood test and the ST segment elevations resolve after normalization of potassium…

…Malignancy: A history suggesting an autoimmune disorder or known malignancy may suggest specific, nonidiopathic etiologies [2]. Summary of Pain Characteristics The following table synthesizes the…

…branch block. Cardiac monitoring is indicated for patients with a high pretest probability of arrhythmia causing syncope. In hospital monitoring is reserved for those wit

…Left heart disease is the most common risk factor for PH. It produces postcapillary PH through elevation of left atrial and pulmonary venous pressure. In…

…disorder characterized by persistently elevated plasma low density lipoprotein cholesterol (LDL C) from early life and a consequent excess risk of premature atherosclerotic cardiovascular disease…

…therefore a disorder of coronary microvascular perfusion rather than persistent obstruction of the treated epicardial segment. The phenomenon occurs in approximately 2%–3% of PCI…

…use disorder and planned follow up , not merely detoxification. Benzodiazepines reduce the severity of withdrawal and the risk of seizures and delirium [1,2]. In…

…Cardiac Amyloidosis Definition and Pathophysiology Cardiac amyloidosis (CA) is a protein misfolding disorder characterized by the extracellular deposition of misfolded fibrillar proteins in the myocardium…

…hypertrophy, it may still be normal when compared to reference values. Figure 1. Types of left ventricular hypertrophy. Left ventricular volume is reduced in conc

…outcome Reported benefit of cessation Cardiovascular disease overall Substantial reduction in cardiovascular events and mortality Established coronary disease Approximately 36% lower risk of premature death…

…Thresholds The thresholds below are used above all in diabetes. The severity of the symptoms and the patient's need for help matter more than…

…a disorder of water balance. The plasma sodium reflects the ratio between the body's exchangeable sodium and potassium and the total body water. In…

…examples of each condition are presented below. The ECG in Brugada syndrome Brugada syndrome is a rare channelopathy (an electrical disorder caused by mutations in…

…50 years for researchers to finally conclude that high cholesterol levels caused coronary artery disease and atherosclerosis in general. This required thousands of observational studies…

…by the combination of symptoms, with or without physical signs, and an LVEF below 40%. Signs may be absent in early disease or after effective…