…several overlapping processes: Recurrent or extensive MI with necrosis and scar formation Diffuse myocardial fibrosis Reversible ischemic dysfunction Chronic hypoperfusion with hibernating myocardium Post ischemic…

…left ventricular dysfunction, peripheral vascular disease and other manifestations of diffuse atherosclerosis. Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are revascularization procedures…

…heterogeneous area whose contents move under pressure; cellulitis instead gives a diffuse oedematous picture without a demarcated fluid collection. Ultrasound also shows the depth of…

…adjacent reference segment presumed to be relatively normal. This assumption may be incorrect when atherosclerosis is diffuse, leading to underestimation of the overall disease burden…

…multivessel coronary artery disease, and diffuse disease increase the likelihood of cardiovascular collapse when PCI fails or flow is severely compromised. Clinical Presentation No reflow…

…stenosis, multivessel coronary artery disease, or diffuse disease. No reflow represents impaired antegrade myocardial perfusion in the absence of a flow limiting epicardial stenosis. It…

…more patients survive with severe, diffuse CAD that is no longer amenable to additional mechanical revascularization. Despite treatment with antianginal drugs and PCI or CABG…

…symptoms (SAMS). These range from diffuse myalgia with a normal CK and no functional impairment to myositis with muscle inflammation and elevated CK. Rhabdomyolysis is…

…is a protein misfolding disorder characterized by the extracellular deposition of misfolded fibrillar proteins in the myocardium, leading to a diffuse infiltrative cardiomyopathy [8, 15]…

…diagnostic. The severity of pain also has limited discriminatory value. Features suggesting myocardial ischaemia Ischaemic discomfort commonly: Is substernal and diffuse. Is described as pressure…

…outer epicardial layers, producing ST elevations over the ischemic zone [15]. In the earliest stages of ischemia, this may manifest as tall, positive hyperacute T…

…In contrast, preserved FFR with reduced CFR may indicate coronary microvascular dysfunction or diffuse epicardial disease. Concordantly normal FFR and CFR are associated with an…

…CMD; epicardial coronary vasospasm; microvascular spasm; endothelial dysfunction; concealed diffuse atherosclerosis; myocardial bridging; myocardial metabolic abnormalities; and abnormal pain perception in patients without demonstrable ischaemia…

…technical factors. Relative perfusion assessment has an important limitation: it requires a normally perfused reference territory. In diffuse coronary disease, balanced multivessel disease, or global…

…Hormonal influences, including oestrogen and progesterone related structural changes in the coronary media. The early postpartum period, when marked hormonal changes occur. Hypertension and oestrogen…

…device therapy eligibility. Ischemic cardiomyopathy, defined by significant CAD (prior MI, diffuse microvascular dysfunction, or flow limiting epicardial stenoses), is the predominant cause, accounting for…

…in the wall of the artery. Such atherosclerotic plaques start building up early in childhood and by middle age, most persons have some degree of…

…causing minimal radiation exposure. It is metabolically inert and diffuses freely across cell membranes, allowing for precise quantification of myocardial blood flow and assessment of…