…Premature menopause Premature ovarian insufficiency Hypertensive disorders of pregnancy Preeclampsia Preterm delivery Gestational diabetes Small for gestational age delivery Placental abruption Pregnancy loss Polycystic ovary…

…Sustained hypoperfusion reduces oxygen and nutrient delivery and, when severe or prolonged, produces multiorgan dysfunction and death. In the setting of ST elevation myocardial infarction …

…gain of function mutations in SCN5A (LQT3). These genetic anomalies disrupt the cardiac ion channels, leading to delayed repolarization and an increased risk of life…

…or delayed percutaneous coronary intervention (PCI). Contraindications Prasugrel should not be used in the following situations: Hypersensitivity to the active substance or any of the…

…thrombotic occlusion of a coronary artery with myocardial necrosis. Although early clinical descriptions emerged at the dawn of the 20th century, widespread acceptance was delayed…

…adrenaline never replace intramuscular adrenaline [1,2]. Delayed administration of adrenaline is associated with more severe and more protracted reactions, biphasic courses and fatal outcome…

…in which the patient reaches hospital early. The benefit of both methods falls steeply with the time since ingestion, and both can harm the patient…

…neutropenic fever is limited, but delayed antibiotics are associated with a worse outcome in sepsis and in several studies of neutropenic patients. In septic shock…

…gain of function mutations in SCN5A (LQT3). These genetic anomalies disrupt the cardiac ion channels, leading to delayed repolarization and an increased risk of life…

…monitoring. The onset of action depends on the route of administration. Intravenous (IV) amiodarone generally acts within 1 to 2 hours. Oral onset is delayed…

…However, intravascular ultrasound has shown that delayed opening of the bridged segment may extend into diastole, so the physiological effect is not limited to systole…

…regardless of the pharmacological route used. In patients with acute coronary syndromes (ACS), the early post event period is particularly vulnerable, and delayed intensification of…

…cardiovascular interventions. Dressler syndrome now occurs in fewer than 1% of AMI cases and is seen predominantly after larger infarctions and/or delayed reperfusion. Its…

…however. Delayed recognition may permit vascular remodelling and renal impairment to develop, leaving persistent hypertension despite correction of the initiating disorder. Earlier diagnosis is associated…

…effects. The class III antiarrhythmic effect is achieved by blocking the delayed rectifier potassium current (IKr), which prolongs the plateau phase of the action potential…

…approach fails to identify a substantial proportion of patients with acute coronary occlusion (ACO) who present without diagnostic ST elevation, often resulting in delayed treatment…

…is believed to be due to delayed (and thus electrically unopposed) depolarization in the ischemic area. Fragmented QRS complex The definition of fragmented QRS complexes (…

…and abnormal QRS complex on the ECG. The hallmark of right bundle branch block is QRS duration ≥0,12 seconds, large R' wave in V1…

…inability of the sinoatrial node to adequately increase its automaticity during physical activity). Sinus arrest & sinus pause (intermittent failures to discharge impulses). Sinoatrial block (delayed…

…rise can cause osmotic demyelination syndrome [1,2]. Hyponatraemia is primarily a disorder of water balance. The plasma sodium reflects the ratio between the body…

…agonist It can cause nausea and delayed gastric emptying. Bear this in mind before sedation and endoscopy DPP 4 inhibitor A low risk of hypoglycaemia…

…on air, or a falling PaO2 Circulation A systolic blood pressure of 100 mmHg or less, a MAP below 65 mmHg, delayed capillary refill, cold…

…the severity of the bleeding clinically Signs of major or ongoing bleeding are: hypotension or a postural drop tachycardia a cold periphery and delayed capillary…

…or mottled. Capillary refill is delayed, and venous filling may be reduced. Other possible findings include muscle stiffening and loss of deep tendon reflexes. Pulses…

…delayed, or selectively after initial medical treatment. The presence of ST segment changes or a positive troponin assay identifies patients in whom an invasive strategy…

…delayed or individualized assessment. Disease specific genetic architecture HCM is predominantly associated with variants affecting sarcomeric proteins, particularly MYH7 and MYBPC3. Approximately 40–60% of…

…material. Clinical Presentation and Symptoms Aortic dissection is an uncommon cause of acute chest pain but carries a particularly high mortality when diagnosis is delayed…

…biomarker evidence of myocardial necrosis, or severe ischaemia on stress testing. Such developments may convert an initially selective or delayed approach into an indication for…

…material. Delayed help seeking is associated with older age, female sex, Black race, lower socioeconomic or uninsured status, a history of angina or diabetes, and…

…between the left atrium and the left ventricle. The deceleration time is prolonged in conditions leading to a delayed equalization of the pressure gradient. Conversely…

…Here, conduction is briefly delayed to allow adequate ventricular filling. The impulse then travels through the Bundle of His, which bifurcates into the left bundle…

…The drugs can also be given sequentially. Hypotension can be counteracted with simultaneous administration of norepinephrine. All patients with severe acute heart failure who receive…

…may be delayed or blocked. These conditions are referred to as atrioventricular (AV) blocks , subdivided according to the degree of block. First , second and third…