…Pharmacology & dosing Definition and pharmacological rationale Bempedoic acid is an oral, small molecule lipid lowering agent used to reduce low density lipoprotein cholesterol (LDL C…

…increase bleeding risk, including oral anticoagulants, clopidogrel, NSAIDs, or fibrinolytics. For patients with active bleeding requiring reversal of prasugrel's pharmacological effect, platelet transfusion may…

…important precautions. A hypertensive emergency is defined by a markedly raised blood pressure in combination with new or progressive acute target organ damage. Common manifestations…

…among the common opioids in renal failure Ketobemidone IV 2.5–5 mg Oral bioavailability about 35 per cent Paracetamol PO or IV 1 g …

…Procedural sedation Propofol, ketamine or a combination. It requires a fasting history, two people, full monitoring and airway preparedness With procedural sedation, one person must…

…those with symptomatic orthostatic hypotension, moderate to severe frailty, or very old or frail patients who may not tolerate rapid blood pressure reduction. Initial Combination…

…statin therapy (Class I recommendation). • Immediate combination with ezetimibe can be considered if LDL C 3.5 mmol/L, possibly initiated during hospitalization (Class IIb…

Cardiology Definition and classification Heart failure with mildly reduced ejection fraction (HFmrEF) is a clinical syndrome defined by the combination of symptoms and/or signs…

…in combination with acetylsalicylic acid (ASA), is indicated for the prevention of atherothrombotic events in adult patients with acute coronary syndrome (ACS) or a prior…

…particularly associated with extensive anterior or transmural infarction, apical dysfunction, LV aneurysm formation, and reduced LV systolic function. The principal mechanisms are the combination of…