Articles & courses

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Digoxin: Dosing, Therapeutic Range and Toxicity Management

…heart failure armamentarium. Its use has declined over time due to the advent of more efficacious agents with wider therapeutic to toxic windows, and its…

Introduction to Cardiac Pacing and Devices: Pacemaker, ICD, CRT

…defibrillator; CRT, cardiac resynchronization therapy) are discussed in subsequent chapters. The first part consists of a brief rehearsal of the basics of cardiac automaticity, action…

Adenosine: Administration Technique, Dose Escalation and Precautions

…respectively. Pharmacokinetics and Administration Technique Adenosine is extensively and rapidly cleared from the plasma by cellular uptake into erythrocytes and vascular endothelial cells. It is…

Drug-Eluting Coronary Stents: Evolution, Evidence and Stent Choice

…scaffold A durable or resorbable polymer coating An antiproliferative drug The drug is delivered from the stent surface and suppresses cellular proliferation and neointimal growth…

SGLT2 Inhibitors for Cardiovascular and Renal Protection

…glycolytic activity in relevant renal and cardiovascular cells. These cellular mechanisms remain proposed explanations for observed clinical effects. Cardiovascular and renal disease associations Diabetes substantially…

Cardiovascular Prevention in the Very Elderly

…functional capacity, and quality of life may be equally important therapeutic objectives. Evidence from randomized trials is often less applicable to very frail or multimorbid…

Cardiac arrest due to electrolyte imbalance

…mEq/L in 24 hours may be targeted. Chronic Hyponatremia ( 48 hours duration): Due to cellular adaptations, rapid correction carries the risk of inducing osmotic…

Heart Failure With Preserved Ejection Fraction: Diagnosis and Treatment

…been described in HFpEF, while nitrosative stress and abnormalities of cellular and molecular myocardial function may further impair contraction and relaxation. Structural and vascular consequences…

Myocardial Ischemia & infarction: Cellular changes, ECG and symptoms

ECG Myocardial ischemia and infarction Myocardial ischemia: cellular changes, ECG signs and development of infarction Like all other cells in the human body, cardiac myocytes…

Bone marrow aspiration and biopsy

…Aspirate and biopsy answer different questions and do not replace one another: the aspirate shows cellular morphology and provides material for flow cytometry and genetics…

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