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🟠 Phentolamine

…®, Rogitine ® Indications Hypertensive crisis. Mechanism of action Phentolamine is a non selective alpha adrenergic blocker. Phentolamine reduces blood pressure while increasing catecholamine activity…

🟠 Clonidine

…emergency Mechanism of action Clonidine is primarily a centrally acting alpha 2 agonist. Stimulation of alpha 2 adrenoceptors in the ventromedial and rostral ventrolateral areas…

🟠 Labetalol

…Postoperative hypertension. Mechanism of action Combined beta adrenergic and alpha adrenergic blocker with rapid onset of action. Labetalol has less antihypertensive efficacy as compared with…

Inotropes and vasopressors: doses, indications, contraindications and effects

…and a beta agonist without vascular effect. Catecholamine receptors Alpha 1 adrenergic receptors: expressed in vascular smooth muscle. Activation results in vasoconstriction and an increase…

Digoxin: Dosing, Therapeutic Range and Toxicity Management

…sodium pump. Digoxin binds reversibly to a specific high affinity site on the extracytoplasmic face of the alpha subunit of the Na+ K+ ATPase. This…

Noradrenaline, Dobutamine and Levosimendan: Practical Infusion Use

…as an agonist of both beta1 and beta2 adrenergic receptors, with variable effects on alpha receptors. Stimulation of beta receptors increases inotropy and chronotropy by…

Sotalol: Initiation, QT Monitoring and Renal Dosing

…virtually all of the beta blocking activity. Sotalol does not block alpha adrenoceptors and lacks sodium channel blocking activity, meaning it exerts no membrane stabilizing…

Cardiac arrest in intoxication (poisoning)

…by means of dialysis. Substance Antidot e Paracetamol (Acetaminophen) N Acetylcysteine Anticholinergics Physostigmine Anticoagulants (apixaban) Andexanet alpha Benzodiazepines Flumazenil The Black Widow, Spider Bett Lactrodectus…

Endocarditis: definitions, causes, diagnosis, echocardiography & treatment

…Previously, alpha streptococcus was the most common agent. These streptococci most often originate from the oral cavity and affect heart valves that have some kind…

Alcohol withdrawal and delirium tremens: quick reference

…for example, beta blockers, alpha 2 agonists and antipsychotics, which mainly affect individual symptoms. Initial management ABCDE and immediate tests Assess the withdrawal and other…

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