…Drug Indications Dosing α1 β1 β2 D1/D2 Effect Adverse effects : : : : : : : : : : : : : Dopamine — low dose Rarely used 0.5–3.0 μg/kg/min + + + +++++ Low…

…of platelet mediated coronary thrombosis after acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI). Aspirin irreversibly inhibits cyclooxygenase and thereby suppresses thromboxane A2 synthesis…

…including modulation of inflammation, oxidative stress, endothelial function, plaque stability, thrombogenic responses and immune activity. Statin intolerance refers to adverse effects attributed to statin treatment…

…acid synthesis and very low density lipoprotein production. Cyclosporine raises LDL cholesterol, partly by reducing LDL receptor availability. Tacrolimus appears to have less adverse effect…

…an effect not shared to the same extent by statins. Inclisiran Inclisiran is a liver targeted small interfering RNA. It promotes degradation of the messenger…

…in females as capable of causing cardiomyopathy. Several mechanisms contribute: Direct toxic effects on cardiomyocytes Disruption of intracellular signalling and protein synthesis Electrical channelopathies Oxidative…

…reductions in four component major adverse cardiovascular events. The reported hazard ratio was 0.83, with a 95% confidence interval of 0.72–0.95…

…related components of atherosclerotic plaque. These effects help explain why reductions in cardiovascular events are substantially greater than the usually modest anatomical regression of coronary…

…shoulder dislocation, with an effect equivalent to sedation and fewer adverse effects Digital nerve block The standard in finger dislocation Procedural sedation Propofol, ketamine or…

…iv. Increase as necessary. Maximum dose: 5 mg iv every six hours. Adverse effects Severe hypotension. Contraindications • Contraindicated in pregnancy, severe renal artery stenosis, severe…