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Bempedoic Acid: Evidence and Clinical Use

…reductions in four component major adverse cardiovascular events. The reported hazard ratio was 0.83, with a 95% confidence interval of 0.72–0.95…

Statin Intolerance and Statin-Associated Muscle Symptoms

…including modulation of inflammation, oxidative stress, endothelial function, plaque stability, thrombogenic responses and immune activity. Statin intolerance refers to adverse effects attributed to statin treatment…

Reduction of dislocations

…shoulder dislocation, with an effect equivalent to sedation and fewer adverse effects Digital nerve block The standard in finger dislocation Procedural sedation Propofol, ketamine or…

🟠 Enalaprilat

…iv. Increase as necessary. Maximum dose: 5 mg iv every six hours. Adverse effects Severe hypotension. Contraindications • Contraindicated in pregnancy, severe renal artery stenosis, severe…

🟠 Clevidipine

…egg), of which the maximum dose per 24 hours is 1000 mL. Adverse effects Headache. Nausea. Fever. Atrial fibrillation. Worsening of heart failure. Caution • Used…

🟠 Esmolol

…min. Maximum infusion dose: 300 μg/kg/min. Bolus doses of 300 μg/kg can be repeated during infusion. Adverse effects Flushing. Nausea…

🟠 Hydralazine

…No effect on venous circulation. • May cause reflex sympathetic stimulation (can be counteracted with simultaneous administration of beta blockers). Effects Induces arteriolar vasodilation without effects…

Adenosine for tachyarrhythmias (AVNRT, AVRT, NCT)

…is not an established drug interaction. The half life of adenosine is 8 seconds. Adverse effects are therefore very brief. Indications Paroxysmal supraventricular tachycardia (PSVT…

Edrophonium test

…test dose without troublesome adverse effects, give a further 8 mg intravenously , slowly. Rapid injection increases the risk of nicotinic effects with paradoxically increasing weakness…

Levosimendan (Simdax, Simendan) in acute heart failure

…the concurrent use of beta blockers. The vasodilating effect reduces preload and afterload, further reducing myocardial workload. 1 The pharmacokinetic profile of levosimendan is modulated…

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