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Ivabradine: Indications, Dosing and Heart-Rate Targets

…current is a mixed inward Na⁺/K⁺ current activated by hyperpolarisation and contributes to spontaneous diastolic depolarisation. By inhibiting the intracellular portion of its transmembrane…

🟠 Drug-Induced Cardiotoxicity

…s) Active Ingredient(s) Cardiotoxicity Label Section DICT Concern Cardiac side effects Severity of cardiotoxicity Hyaluronic Acid HYALURONIC ACID HYALURONIC ACID NA no no ZYPREXA…

Reduction of dislocations

…sedation and fewer adverse effects Digital nerve block The standard in finger dislocation Procedural sedation Propofol, ketamine or a combination. It requires a fasting history…

🟠 Enalaprilat

…iv. Increase as necessary. Maximum dose: 5 mg iv every six hours. Adverse effects Severe hypotension. Contraindications • Contraindicated in pregnancy, severe renal artery stenosis, severe…

🟠 Clevidipine

…of postoperative hypertension. Mechanism of action Ultra short acting calcium channel blocker (CCB). Half life: 5 minutes. Rapidly inactivated by esterases. Effects • Clevidipine is a…

🟠 Esmolol

…min. Maximum infusion dose: 300 μg/kg/min. Bolus doses of 300 μg/kg can be repeated during infusion. Adverse effects Flushing. Nausea…

🟠 Hydralazine

…No effect on venous circulation. • May cause reflex sympathetic stimulation (can be counteracted with simultaneous administration of beta blockers). Effects Induces arteriolar vasodilation without effects…

Adenosine for tachyarrhythmias (AVNRT, AVRT, NCT)

…is not an established drug interaction. The half life of adenosine is 8 seconds. Adverse effects are therefore very brief. Indications Paroxysmal supraventricular tachycardia (PSVT…

Edrophonium test

…the test dose without troublesome adverse effects, give a further 8 mg intravenously , slowly. Rapid injection increases the risk of nicotinic effects with paradoxically increasing…

Levosimendan (Simdax, Simendan) in acute heart failure

…A recent echocardiographic examination should be available or performed urgently to evaluate ventricular and valvular function. Levosimendan drug is generally well tolerated. Severe adverse effects…

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