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Pharmacologic agents in myocardial perfusion imaging

…of adenosine into endothelial cells. Further, it inhibits adenosine deaminase, which is responsible for breaking down adenosine. These actions result in increased extracellular adenosine concentrations…

Adenosine: Administration Technique, Dose Escalation and Precautions

…adenosine is rapidly injected intravenously at initial doses of 6 to 12 mg, followed by a flush. Doses as low as 2.5 mg may…

Adenosine for tachyarrhythmias (AVNRT, AVRT, NCT)

…degree Mobitz type 2 AV block, third degree AV block). Sick sinus syndrome or symptomatic bradycardia in the absence of a pacemaker. Hypersensitivity to adenosine…

Myocardial Ischemia & infarction: Cellular changes, ECG and symptoms

…Like all other cells in the human body, cardiac myocytes use ATP (adenosine triphosphate) as the primary energy source. ATP is produced by metabolizing carbohydrates …

Oesophageal ECG

…needs to be documented before referral to an arrhythmia unit. Assessment of the effect of adenosine, which can be given during the recording and unmask…

🟠 Ticagrelor (Brilinta, Brilique)

…the initial one year treatment with Ticagrelor 90 mg or treatment with another adenosine diphosphate (ADP) receptor inhibitor for patients who had coronary syndrome and…

Bempedoic Acid: Evidence and Clinical Use

…the same broad cholesterol synthesis pathway as statins. The principal molecular target is adenosine triphosphate citrate lyase (ACL), a cytosolic enzyme upstream of 3 hydroxy…

Isoprenaline and Dopamine Infusions for Bradycardia

…blockers, antiarrhythmic drugs (amiodarone, dronedarone, sotalol, flecainide, propafenone, procainamide, disopyramide, adenosine, digoxin, ivabradine), psychoactive and neuroactive drugs (lithium, phenothiazine, phenytoin, carbamazepine), and various chemotherapeutic agents…

Noradrenaline, Dobutamine and Levosimendan: Practical Infusion Use

…effects on alpha receptors. Stimulation of beta receptors increases inotropy and chronotropy by elevating intracellular cyclic adenosine monophosphate (cAMP) and calcium, as well as through…

Digoxin - ECG changes, arrhythmias, conduction defects & treatment

…heart rate. The positive inotropic effect is due to the inhibition of the sodium potassium adenosine triphosphatase (NaK ATPase) in the ventricular myocardium. Inhibition of…

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