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Atrial fibrillation: ECG, classification, causes, risk factors & management

…the use of medications that slow ventricular rate (beta blockers being the mainstay of this therapy). Rate control does not affect the rhythm per se …

Antianginal Therapy: Beta-Blockers, Calcium Channel Blockers, Nitrates, and Ranolazine

…When prescribed for antianginal purposes in CCS, the target resting heart rate is generally 55–60 beats per minute. Beta blockers also have prognostic value…

Cardiac arrest due to anaphylaxis

…and drug induced reactions. Approximately 90% of anaphylactic cardiac arrests present with pulseless electrical activity (PEA) as the initial rhythm, while the remainder manifest ventricular…

Introduction to Cardiac Pacing and Devices: Pacemaker, ICD, CRT

…The cells of the sinus node have an intrinsic rate of depolarization at approximately 70 times per minute, which results in 70 contractions per minute…

Colchicine and Anti-inflammatory Therapy in Coronary Disease

…pressure or other conventional risk factors. Colchicine is an established anti inflammatory drug that may inhibit inflammasome activity, reduce interleukin 1β and interleukin 6…

Sotalol: Initiation, QT Monitoring and Renal Dosing

Arrhythmias and arrhythmology Pharmacology & dosing Definition and Pathophysiology Sotalol is a nonselective beta adrenoceptor blocker devoid of intrinsic sympathomimetic activity that also prolongs cardiac repolarization…

Cardiac Rehabilitation After Myocardial Infarction

…infarction physical activity programmes into a structured centre of secondary cardiovascular prevention in which exercise, lifestyle intervention, education, and guideline directed medical therapy are integrated…

PCSK9 Inhibitors: Indications, Efficacy and Access

…clearance of circulating LDL cholesterol (LDL C). Increased PCSK9 activity therefore contributes to higher LDL C concentrations. The genetic evidence provides the rationale for therapeutic…

Digoxin: Dosing, Therapeutic Range and Toxicity Management

…via the autonomic nervous system. It attenuates carotid sinus baroreceptor activity and acts centrally and peripherally to enhance vagal tone. These sympatho inhibitory effects decrease…

Statin Intolerance and Statin-Associated Muscle Symptoms

…responses and immune activity. Statin intolerance refers to adverse effects attributed to statin treatment that improve or resolve after reducing the dose or stopping therapy…

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