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Introduction to Coronary Artery Disease (Ischemic Heart Disease)

…symptoms disappear within minutes after stopping the activity. The greater the stenosis, the lower the level of myocardial workload required to elicit ischemia and symptoms…

Noradrenaline, Dobutamine and Levosimendan: Practical Infusion Use

…It enhances myocardial contractility and induces peripheral vasodilation through cardiac myofilament calcium sensitisation. This process is achieved via calcium dependent binding to troponin C during…

Digoxin: Dosing, Therapeutic Range and Toxicity Management

…ATPase. This binding is entropically driven and preferentially occurs after the phosphorylation of a beta aspartate on the cytoplasmic face of the alpha subunit, thereby…

Physics of myocardial perfusion imaging (SPECT, PET): Radiotracers, perfusion, blood flow and viability

…high extraction from blood to tissue and high retention, with a linear relationship between myocardial blood flow and measured tracer activity over a wide range …

Physical Activity Prescription for Cardiovascular Prevention

…Assessment Before Prescription Physical activity should be assessed and prescribed using the components of: Frequency Intensity Time or duration Type Progression The prescription should be…

Ventricular fibrillation, pulseless electrical activity and sudden cardiac arrest

…causing rapid and chaotic ventricular depolarizations, rendering the left ventricle incapable of generating effective contractions. This results in circulatory collapse, loss of consciousness, and sudden…

Sotalol: Initiation, QT Monitoring and Renal Dosing

…d and l isomers, which share similar efficacy in prolonging repolarization. However, the l isomer is responsible for virtually all of the beta blocking activity…

Status epilepticus: quick reference for emergency treatment

…minutes of continuous convulsive activity, t2, the risk of permanent neuronal injury increases. Treatment must therefore start at 5 minutes and be escalated without unnecessary…

🟠 Phentolamine

…crisis. Mechanism of action Phentolamine is a non selective alpha adrenergic blocker. Phentolamine reduces blood pressure while increasing catecholamine activity. Effects Primarily causes afterload reduction…

Atrial Flutter: Mechanisms, ECG Recognition and Management

…and Pathophysiology Atrial flutter is defined by a macroreentrant atrial circuit, which manifests on the electrocardiogram (ECG) as organized, continuous atrial electrical activity. This activity…

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