TheCardiovascular
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D81.82 Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

BackD81Combined immunodeficiencies10 →D81.0Severe combined immunodeficiency [SCID] with reticular dysgenesisD81.1Severe combined immunodeficiency [SCID] with low T- and B-cell numbersD81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbersD81.3Adenosine deaminase [ADA] deficiency4 →D81.30Adenosine deaminase deficiency, unspecifiedD81.31Severe combined immunodeficiency due to adenosine deaminase deficiencyD81.32Adenosine deaminase 2 deficiencyD81.39Other adenosine deaminase deficiencyD81.4Nezelof's syndromeD81.5Purine nucleoside phosphorylase [PNP] deficiencyD81.6Major histocompatibility complex class I deficiencyD81.7Major histocompatibility complex class II deficiencyD81.8Other combined immunodeficiencies3 →D81.81Biotin-dependent carboxylase deficiency3 →D81.810Biotinidase deficiencyD81.818Other biotin-dependent carboxylase deficiencyD81.819Biotin-dependent carboxylase deficiency, unspecifiedD81.82Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]D81.89Other combined immunodeficienciesD81.9Combined immunodeficiency, unspecified
CategoryCODABLE
D81.82
Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
EXAMPLES
p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease
CODING RULE
Code also: , if applicable, any associated manifestations, such as:
bronchiectasis (J47.-)
herpes virus infections (B00.-)
other acute respiratory tract infections (J00-J06; J20-J22)
other infections (A00-B99)
pneumonia (J12-J18)
Chapter
III · Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Section
D80-D89
Valid from
Source

CMS ICD-10-CM Tabular List, edition FY2026.

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