12 träffar

DrugDirect thrombin inhibitor (factor IIa)
Dabigatran

…acting antidote — idarucizumab achieves complete reversal within minutes, which weighs heavily in patients who may need emergency surgery. The price is that approximately 80 % of…

DrugSelective dopamine-1 receptor agonist
Fenoldopam

…agonist The only antihypertensive that increases renal perfusion while blood pressure falls. A selective D1 agonist without alpha or beta effects, with onset within minutes…

DrugRapid-acting insulin analogue
Insulin aspart

…healthcare and simultaneously the insulin used for intravenous infusion in diabetic ketoacidosis and hyperosmolar hyperglycaemic state. Subcutaneously it has an onset within 10–20 minutes…

DrugIndirect thrombin and factor Xa inhibitor via antithrombin
Heparin (unfractionated)

…to two hours, the effect can be measured in real time with APTT, and it can be neutralised completely with protamine within minutes. This is…

DrugLong-acting benzodiazepine with active metabolite
Diazepam

…fast and reliable — high lipid solubility gives onset within a couple of minutes intravenously, and the rectal solution works when no intravenous access is available…

DrugConcentrated carbohydrate solution for acute hypoglycaemia
Glucose (concentrated, IV)

…hypoglycaemia The first-line treatment for severe hypoglycaemia in a patient who cannot swallow and in whom intravenous access is available. The effect arrives within…

DrugInhaled corticosteroid in fixed combination with long-acting β₂-agonist
Budesonide/formoterol

…agonist Formoterol is the only long-acting β₂-agonist with onset within a few minutes, and that property is precisely what makes the combination useful…

DrugPancreatic hormone, glycogenolytic agent and inotrope
Glucagon

…unavailable — the effect arrives within ten minutes through hepatic glycogenolysis. In beta-blocker intoxication, glucagon is instead an inotrope that bypasses the blocked beta receptor…

DrugDirect factor Xa inhibitor
Apixaban

…dosing and no routine monitoring. Lower risk of intracranial haemorrhage than warfarin — but the short half-life means a missed dose has consequences within hours.

DrugMuscarinic receptor antagonist (vagolytic)
Atropine

…which is the entire explanation for why the drug is ineffective in infranodal block. The effect comes within one minute and fades over an hour…

DrugCalcium salt for intravenous membrane stabilisation and calcium supplementation
Calcium gluconate

…with ECG changes: calcium restores the margin between resting membrane potential and threshold potential and protects the myocardium against arrhythmia within minutes — but does not…

DrugNon-selective α-adrenergic blocker
Phentolamine

Regitin Rogitine OraVerse Non-selective α-adrenergic blocker Non-selective alpha-blocker with onset within minutes and duration under half an hour. A niche drug…