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Invasive Coronary Angiography: Indications and Vascular Access

…measurements permit assessment of the physiological significance of selected stenoses using fractional flow reserve (FFR) and instantaneous wave free ratio (iFR). Other invasive techniques can…

Carotid Artery Disease: Screening, Medical Therapy and Revascularisation

…at least two vascular beds. Carotid disease therefore commonly coexists with coronary artery disease (CAD), peripheral artery disease (PAD), and other manifestations of systemic atherosclerosis…

Peripheral Artery Disease: Diagnosis, Ankle–Brachial Index and Risk Management

Cardiology Clinical medicine Definition and pathophysiology Peripheral artery disease (PAD) is a clinical disorder caused by stenosis or occlusion of the aorta or arteries supplying…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…regulate vascular tone, preserve an antithrombotic surface, and control the adhesion and migration of inflammatory cells. Dyslipidaemia, cigarette smoking, hypertension, diabetes mellitus and other adverse…

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…and turbulent hemodynamic shear stress. This dysfunction compromises the endothelial barrier, upregulating the expression of vascular cell adhesion molecule 1 (VCAM 1) and intercellular adhesion…

In-Stent Restenosis: Mechanisms and Treatment

…diameter A high degree of residual stenosis Long lesion length Diabetes Untreated edge dissection DES have reduced restenosis compared with BMS, and newer generation DES…

Approach to patients with chest pain: differential diagnoses, management & ECG

…are numerous other causes of chest pain, but the other causes are either subacute or non acute. The history taking must be systematic and accurate…

Familial Hypercholesterolaemia: Diagnosis, Cascade Screening and Treatment

…The magnitude of untreated LDL C elevation. The presence and age of onset of premature CAD or other vascular disease. A history of myocardial infarction…

Myocardial Perfusion Imaging With SPECT and PET

…the ratio of stress myocardial blood flow to resting myocardial blood flow. It provides an integrated measure influenced by epicardial stenosis, diffuse atherosclerosis, and coronary…

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Multivessel Coronary Artery Disease

…ventricular dysfunction, peripheral vascular disease and other manifestations of diffuse atherosclerosis. Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are revascularization procedures. Both…

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