…dosing and no routine monitoring. Lower risk of intracranial haemorrhage than warfarin — but the short half-life means a missed dose has consequences within hours.

…Sweden and the one with the least cardiovascular risk at a low dose. A short half-life of around 2 hours means the effect arrives…

…meals and overnight, with a largely flat profile over 24 hours and therefore a lower risk of nocturnal hypoglycaemia than NPH insulin. It is titrated…

…in the class — the increase in risk for myocardial infarction, stroke, and heart failure resembles that of selective COX-2 inhibitors and is seen already…

…symptomatic patient with HFrEF who remains above 70 beats per minute despite maximally tolerated beta-blockade, where SHIFT demonstrated reduced risk of heart failure hospitalisation.

…potassium by a tenth of a millimole. Insulin-glucose, beta-agonists, and dialysis must be started in parallel, otherwise the arrhythmia risk returns when the…

…short notice. The disadvantages are continuous infusion, an unpredictable dose–response relationship due to binding to plasma proteins, and the risk of heparin-induced thrombocytopenia.

…choose when reversibility matters. With a half-life of 9 minutes and the effect gone 20–30 minutes after the infusion ends, it is useful…

…a half-life of one to two days and the active metabolite desmethyldiazepam up to four, so the concentration continues to rise for a week…

…40 mmol per hour in life-threatening hypokalaemia under continuous ECG monitoring. Hypokalaemia that refuses to rise despite adequate replacement is almost always caused by…

…mg, while the adverse effect curves for potassium, sodium, urate, and glucose continue to rise — higher doses therefore purchase side effects without blood pressure benefit…