…to two hours, the effect can be measured in real time with APTT, and it can be neutralised completely with protamine within minutes. This is…

…antihypertensive that increases renal perfusion while blood pressure falls. A selective D1 agonist without alpha or beta effects, with onset within minutes and duration under…

…eliminated renally, so renal function governs treatment entirely. Dyspepsia affects one in ten patients and is the most common reason for discontinuation in clinical practice.

…arrives and resolves quickly, which is an advantage: the drug suits as-needed use and can be discontinued with rapid recovery of renal function and…

…DELIVER showed equivalent benefit with preserved and mildly reduced EF, and DAPA-CKD demonstrated slowed renal function decline and reduced mortality in chronic kidney disease…

…and the easiest calcium channel blocker to use: once-daily dosing, a half-life of almost two days, and no dose adjustment in renal impairment…

…entirely free of sedation: a distinct minority of patients become drowsy, and this should be asked about in professional drivers. Renal function governs the dose.

…heart failure events regardless of ejection fraction in EMPEROR-Reduced and EMPEROR-Preserved, and slowed renal function decline down to eGFR 20 in EMPA-KIDNEY…

…curve, not a line: below the threshold nothing happens, and in renal failure the threshold dose must be raised to achieve any effect at all.

…dose range and three-times-daily regimen. Used in peripheral neuropathic pain and as adjunctive treatment in focal epilepsy. Excreted unchanged renally, making renal function…

…Den aktiva metaboliten morfin-6-glukuronid utsöndras renalt och ackumuleras vid njursvikt — det förklarar varför äldre med nedsatt njurfunktion blir sederade på en dos som…

…och kan laddas intravenöst utan blodtrycksfall eller EKG-övervakning. Nästan hela dosen utsöndras renalt i oförändrad form, vilket gör njurfunktionen till den enda variabel som…

…går att lita på. Oxazepam är själv en metabolit och behöver ingen oxidativ fas 1-metabolism — den glukuronideras direkt och utsöndras renalt, utan aktiva nedbrytningsprodukter…