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Microvascular Angina and INOCA: Diagnosis with CFR and IMR

…despite normal or non obstructive coronary arteries; dyspnoea; fatigue; and recurrent symptoms causing impaired quality of life. Women with suspected angina are more likely than…

Principles of myocardial perfusion imaging (SPECT, PET), coronary blood flow and flow reserve (CFR)

Cardiology Principles of myocardial perfusion imaging Myocardial perfusion imaging (MPI) is a non invasive technique for detecting and quantifying coronary artery disease (CAD). It offers…

Diagnostic Criteria for Acute Myocardial Infarction: Cardiac troponins, ECG & Symptoms

…is the most severe complication of coronary artery disease. The most common initiating mechanism is rupture or erosion of a vulnerable (unstable) atherosclerotic coronary plaque…

Metabolic Syndrome: Definition and Clinical Significance

…associated fatty liver disease is also independently related to cardiovascular disease, particularly coronary artery disease. Hyperuricaemia and Endothelial Dysfunction Insulin resistance impairs renal tubular handling…

Acute Coronary Syndrome: Definitions and Initial Triage

…lower threshold for symptom provocation; or angina occurring after a recent MI. Myocardial injury is separate from MI. It refers to cardiac troponin release that…

Cardiac troponin I (TnI) and T (TnT): Interpretation and evaluation in acute coronary syndromes

…be chronically elevated in patients with renal failure, this is more pronounced for troponin T ( Seng et al ). Troponin I rises faster than troponin T…

Unstable Angina: Definition and Contemporary Management

…release must therefore be considered throughout assessment. Coronary disease is most commonly related to atheromatous plaque producing progressive narrowing or obstruction of epicardial coronary arteries…

In-Stent Restenosis: Mechanisms and Treatment

…restenosis (ISR) is recurrent narrowing within a previously implanted coronary stent. It represents a form of arterial hyperplastic disease arising after percutaneous coronary intervention (PCI)…

Chest Pain in the Emergency Department: Diagnostic Pathways

…myocardial ischaemia caused by an acute coronary process. Myocardial injury leads to release of cardiac troponin, but troponin elevation is not specific for myocardial infarction…

Myocardial Injury Versus Infarction: Interpreting Troponin Elevation

…Increased concentrations may result from acute coronary atherothrombosis, oxygen supply–demand imbalance, direct myocardial injury, systemic illness, structural heart disease, or several mechanisms acting simultaneously…

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