…syndrome (LQTS) is characterised by an abnormal prolongation of the QT interval on the surface electrocardiogram (ECG), which predisposes the myocardium to a specific form…

…on dialysis, where DOACs lack documentation or have only weak evidence. Venous thromboembolism when a DOAC cannot be used (interactions, cost, adherence, pregnancy after the…

…generally not recommended. If deemed necessary after careful individual benefit risk assessment by the prescribing physician: Initial dose : 60 mg single loading dose. Maintenance dose…

…despite maximally tolerated therapy. It is a prodrug activated predominantly in the liver by very long chain acyl CoA synthetase 1. This activating enzyme is…

…and unstable angina. The initial clinical distinction depends on symptoms, serial electrocardiography, and cardiac troponin findings. The default treatment after ACS, whether or not PCI…

…after the phosphorylation of a beta aspartate on the cytoplasmic face of the alpha subunit, thereby stabilizing the E2P conformation of the enzyme. By inhibiting…

…event while receiving maximally tolerated statin therapy, an LDL C goal below 1.0 mmol/L (<40 mg/dL) may be considered. The cited recommendations…

…one ASCVD risk equivalent who were receiving statins, inclisiran produced a further reduction in LDL C of approximately 50%. The effect was consistent in patients…

…reduction varies according to the statin, dose, and individual response. In general, statins reduce LDL C by approximately 30–55%; doubling the dose produces an…

…receiving maximally tolerated statin therapy, an LDL C goal below 1.0 mmol/L (<40 mg/dL) may be considered in the circumstances specified by…

…preferably while the patient is receiving a stable diuretic dose. Other clinical contexts Secondary causes should be pursued when abnormalities are identified on initial testing…

…flutter. Each P wave is followed by a QRS complex; atrioventricular block is uncommon unless the patient is receiving digoxin. The ventricular rate is regular…

…depends on the coronary anatomy and clinical setting. Beta blockers Mechanism and clinical role Beta blockers reduce myocardial oxygen demand and provide symptomatic relief by…

…by diaphoresis, dyspnoea, nausea, vomiting, fatigue, faintness, or belching. Radiation to both arms or shoulders has a particularly strong association with myocardial infarction in the…

…anginal equivalents include: Dyspnoea on exertion. Fatigue. Dizziness during exertion. Discomfort in the arm, jaw, neck, or upper back. Chest discomfort triggered by emotional stress…