…the subendothelial accumulation of apolipoprotein B containing lipoproteins, macrophage infiltration, smooth muscle cell proliferation, and extracellular matrix deposition, ultimately leading to the formation of atherosclerotic…

…innate and adaptive inflammatory leukocytes; oxidative stress and persistent local inflammation; smooth muscle cell migration and proliferation; extracellular matrix synthesis and degradation; neovascularization and intraplaque…

…initiate a sustained inflammatory and reparative response. Proliferation and accumulation of tissue within the stent progressively reduce the lumen. The stent scaffold prevents the external…

…scaffold A durable or resorbable polymer coating An antiproliferative drug The drug is delivered from the stent surface and suppresses cellular proliferation and neointimal growth…