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Stroke Prevention in Atrial Fibrillation: Choosing Anticoagulation

…The presence of mitral stenosis, a mechanical heart valve or hypertrophic cardiomyopathy. Heart failure, hypertension, diabetes and vascular disease. Age and sex category. Renal and…

Carotid Artery Disease: Screening, Medical Therapy and Revascularisation

…at least two vascular beds. Carotid disease therefore commonly coexists with coronary artery disease (CAD), peripheral artery disease (PAD), and other manifestations of systemic atherosclerosis…

Hypertensive Emergency and Urgency: Differentiation and Treatment

…of vascular autoregulation during a rapid or severe rise in BP. This may produce acute injury in the brain, retina, heart, aorta, kidneys, or other…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…regulate vascular tone, preserve an antithrombotic surface, and control the adhesion and migration of inflammatory cells. Dyslipidaemia, cigarette smoking, hypertension, diabetes mellitus and other adverse…

ST-Elevation Myocardial Infarction: Diagnosis and Electrocardiographic Criteria

…proportion of painless or silent STEMIs is greater in patients with diabetes mellitus and increases with age. STEMI may present as sudden onset breathlessness. Other…

Acute Pulmonary Embolism: Risk Stratification and Reperfusion

…and death. The clinical consequences are particularly important when pulmonary vascular obstruction is accompanied by limited cardiopulmonary reserve or other adverse comorbidity. The classification of…

Peripheral Artery Disease: Diagnosis, Ankle–Brachial Index and Risk Management

…in older people and in patients with diabetes. The haemodynamic consequences depend on lesion location, severity, length, the presence of multilevel disease and collateral circulation…

Chronic Kidney Disease as a Cardiovascular Risk Factor

…The cardiovascular burden of CKD extends beyond CAD to peripheral arterial disease, cerebrovascular disease, valvular heart disease, heart failure, atrial fibrillation, and other arrhythmias or…

Vasospastic (Prinzmetal) Angina: Provocation Testing and Treatment

…are incompletely defined. Proposed contributors include hypercontractility or hypersensitivity of coronary vascular smooth muscle to vasoconstrictor stimuli, including adrenergic agonists, leukotrienes, and serotonin. In patients…

Atrial Fibrillation in the Critically Ill Patient

…to vascular dementia, and thromboembolism may affect organs other than the brain. Patients with AF in the setting of ACS have more comorbidities and a…

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