…considered independently. For cardiometabolic health, the most favourable patterns generally contain more minimally processed, fibre rich and bioactive foods, including fruits, non starchy vegetables, beans…

…severe, myocardial necrosis. It most commonly reflects atherothrombosis: disruption of an atherosclerotic plaque followed by platelet activation and coagulation, with formation of an intraluminal thrombus…

…occur in vessels with little or no lipid core, rich proteoglycans, and many smooth muscle cells, leading to a white, platelet rich thrombus. Myocardial vulnerability…

…predominantly platelet rich because they form under high shear conditions. Disruption of an atherosclerotic plaque or injury associated with PCI exposes thrombogenic material, promoting platelet…

…microenvironment is rich in hyaluronan, toll like receptor 2 (TLR2), and neutrophil extracellular traps (NETs). Thrombi formed via erosion are typically platelet rich and less…

…and elastic tissue, fragmentation of the internal elastic lamina, and superimposed platelet and fibrin rich thrombus. Lesions preferentially occur at arterial branch points, where disturbed…

…Smooth muscle cells (SMCs) migrate from the tunica media into the intima, driven by platelet derived growth factor (PDGF) and other cytokines. Within the intima…

…or other atherosclerotic vascular disease. Antiplatelet therapy is a central component because platelet activation and aggregation contribute importantly to arterial thrombus formation, recurrent coronary occlusion…

…and platelet aggregation. Because aspirin affects only one pathway of platelet activation, its antiplatelet effect is relatively limited compared with agents that inhibit other platelet…

…receptor inhibitor. It is central to the prevention of platelet mediated coronary thrombosis after acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI). Aspirin irreversibly…