…Each atherogenic lipoprotein particle carries one apoB molecule. Consequently, the plasma apoB concentration approximates the number of circulating atherogenic particles rather than the amount of…

…the ward Situation Target plasma glucose : : Most inpatients 6–10 mmol/L Frail older people, a short expected survival, a high risk of hypoglycaemia 8…

…pathophysiology Familial hypercholesterolaemia (FH) is an inherited disorder characterized by persistently elevated plasma low density lipoprotein cholesterol (LDL C) from early life and a consequent…

…a high risk even if the plasma potassium is below 6.5 mmol/L. Conversely, patients with chronic renal failure may have very high values…

…of poisons. Stabilisation according to ABCDE, the plasma glucose, a blood gas and an ECG all come before complete identification of the substance. Treatment of…

… sotagliflozin is a related dual SGLT1/SGLT2 inhibitor. SGLT2 is a high capacity, low affinity transporter situated in the S1 and S2 segments of the…

…A very high glucose value is no longer required [1]. Diabetic ketoacidosis, DKA Hyperosmolar hyperglycaemic state, HHS : : : Glucose Plasma glucose ≥ 11.1 mmol/L or…

…disease Stage eGFR Description : : : G1 ≥ 90 Normal or high G2 60–89 Mildly reduced G3a 45–59 Mildly to moderately reduced G3b 30–44 Moderately…

…The hypotensive effect of enalaprilat depends on plasma volume and plasma renin activity. Volume depletion and high plasma renin activity increase the effect of enalaprilat…

…sodium pump. Digoxin binds reversibly to a specific high affinity site on the extracytoplasmic face of the alpha subunit of the Na+ K+ ATPase. This…