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Secondary Hypertension: When and How to Investigate

…This includes: Poor adherence to antihypertensive treatment White coat hypertension Other contributors to apparently uncontrolled blood pressure Adherence should initially be explored carefully through direct…

Familial and Genetic Screening in Premature Cardiovascular Disease

…Familial and genetic screening in cardiovascular medicine is the systematic assessment of relatives and other individuals who may carry an inherited predisposition to cardiovascular disease…

Differential Diagnosis of Chest Pain: A Clinical Overview

…Malignancy: A history suggesting an autoimmune disorder or known malignancy may suggest specific, nonidiopathic etiologies [2]. Summary of Pain Characteristics The following table synthesizes the…

Cardiovascular Risk in Women: Sex-Specific Factors

…Female specific or female predominant factors associated with later cardiovascular risk include: Premature menopause Premature ovarian insufficiency Hypertensive disorders of pregnancy Preeclampsia Preterm delivery Gestational…

The Fourth Universal Definition of Myocardial Infarction: Types 1–5

…evidence of acute myocardial ischaemia, electrocardiographic findings, cardiac biomarkers, imaging, angiography, and, occasionally, pathological examination. Pathologically, infarction represents myocardial cell death caused by prolonged ischaemia…

Cardiovascular Risk Assessment with SCORE2 and SCORE2-OP

…competing risk of death from non cardiovascular causes, an important consideration in older populations. Risk prediction is particularly relevant in adults with elevated blood pressure…

Chest Pain in the Emergency Department: Diagnostic Pathways

…Myocardial injury leads to release of cardiac troponin, but troponin elevation is not specific for myocardial infarction. Other conditions may produce cardiomyocyte injury and elevated…

Invasive Coronary Angiography: Indications and Vascular Access

…and lesion haziness raise suspicion of thrombus, although haziness is not specific. Intravascular imaging can identify plaque disruption, thrombus and other structural features that may…

Brugada syndrome: ECG, clinical features and management

…of Brugada syndrome are fairly specific to the disorder, provided that the clinical characteristics are in line with the disorder. There are however other disorders…

Familial Hypercholesterolaemia: Diagnosis, Cascade Screening and Treatment

…an inherited disorder characterized by persistently elevated plasma low density lipoprotein cholesterol (LDL C) from early life and a consequent excess risk of premature atherosclerotic…

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