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The Fourth Universal Definition of Myocardial Infarction: Types 1–5

…cTn) concentration above the assay specific 99th percentile upper reference limit (URL). It is considered acute when there is a rise and/or fall in…

Cardiovascular Risk in Women: Sex-Specific Factors

…reproductive and pregnancy related history. Female specific or female predominant factors associated with later cardiovascular risk include: Premature menopause Premature ovarian insufficiency Hypertensive disorders of…

Chest Pain in the Emergency Department: Diagnostic Pathways

…Atherosclerotic and thromboembolic risk factors. Relevant predispositions, such as connective tissue disease. No single pain descriptor is diagnostic. The severity of pain also has limited…

Secondary Hypertension: When and How to Investigate

…remodelling and renal impairment to develop, leaving persistent hypertension despite correction of the initiating disorder. Earlier diagnosis is associated with a greater likelihood of cure…

Familial and Genetic Screening in Premature Cardiovascular Disease

…and thromboembolic disorders. Most recognised heritable cardiovascular conditions demonstrate autosomal dominant transmission, in which an affected heterozygous individual has a 50% risk of transmitting the…

Cardiovascular Risk Assessment with SCORE2 and SCORE2-OP

…adults with elevated blood pressure (BP), in whom absolute cardiovascular risk varies considerably according to age and the presence of concomitant risk factors. In contrast…

Invasive Coronary Angiography: Indications and Vascular Access

…measurements permit assessment of the physiological significance of selected stenoses using fractional flow reserve (FFR) and instantaneous wave free ratio (iFR). Other invasive techniques can…

Brugada syndrome: ECG, clinical features and management

…of Brugada syndrome are fairly specific to the disorder, provided that the clinical characteristics are in line with the disorder. There are however other disorders…

Differential Diagnosis of Chest Pain: A Clinical Overview

…autoimmune disorder or known malignancy may suggest specific, nonidiopathic etiologies [2]. Summary of Pain Characteristics The following table synthesizes the key differential diagnoses and their…

ECG changes due to electrolyte imbalance (disorder)

…there is a correlation between the severity of electrolyte imbalance and the visible ECG changes. Specific electrolyte disorders 1. Sodium Increased (hypernatremia) and decreased (hyponatremia)…

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