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Antiplatelet Therapy in Secondary Prevention After Myocardial Infarction

…coronary or other atherosclerotic vascular disease. Antiplatelet therapy is a central component because platelet activation and aggregation contribute importantly to arterial thrombus formation, recurrent coronary…

De-escalation and Shortened Dual Antiplatelet Therapy in Patients at High Bleeding Risk

…acute coronary syndrome (ACS), DAPT is used to reduce recurrent myocardial infarction, stent thrombosis and other ischemic events after coronary angiography, percutaneous coronary intervention (PCI…

In-Stent Restenosis: Mechanisms and Treatment

Myocardial ischemia and infarction Definition and Clinical Significance In stent restenosis (ISR) is recurrent narrowing within a previously implanted coronary stent. It represents a form…

Acute coronary syndrome: quick reference for loading doses and time targets

…dangerous differential diagnoses [1,2]. STEMI and other ECG patterns suggesting acute coronary occlusion are time dependent conditions. The decision on immediate reperfusion is based…

LDL Cholesterol Targets Across Cardiovascular Risk Categories

…C) is the principal therapeutic target in lipid management because LDL and other apolipoprotein B containing lipoproteins play a causal role in atherosclerotic cardiovascular disease…

Smoking Cessation: Pharmacotherapy and Cardiovascular Benefit

…with avoidance of second hand smoke and, where possible, other inhaled nicotine products. In cardiovascular medicine, the objective is not merely to reduce cigarette consumption…

Complete Versus Culprit-Only Revascularization in Acute Coronary Syndrome

…flow limiting disease may continue to cause ischaemia, recurrent symptoms, myocardial infarction, or other major adverse cardiovascular events. Complete revascularization is therefore considered an important…

Tachycardia induced cardiomyopathy

…left ventricular dysfunction among patients with atrial fibrillation and other supraventricular tachyarrhythmias. Moreover, ventricular tachyarrhythmias (including recurrent episodes of ventricular tachycardia) can also cause this…

ACE Inhibitor Cough and Angioedema: Practical Management

…the sensitization of sensory nerve endings due to the accumulation of bradykinin. ACE is responsible for metabolizing bradykinin and other tachykinins, such as substance P…

Colchicine and Anti-inflammatory Therapy in Coronary Disease

…Its cardiovascular effects therefore appear to reflect modulation of vascular inflammation rather than lipid lowering. Other anti inflammatory strategies have produced less favourable results. Canakinumab…

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