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LDL Cholesterol Targets Across Cardiovascular Risk Categories

…modest absolute reduction may be clinically important in individuals at high or very high risk. Prolonged exposure to lower LDL C concentrations is associated with…

Contrast-Associated Acute Kidney Injury: Risk Assessment and Prevention

…In many cases, the renal injury probably represents acute tubular necrosis arising from the combined effects of contrast exposure and other ischaemic or nephrotoxic stresses…

🟠 Ticagrelor (Brilinta, Brilique)

…ritonavir, and atazanavir) can lead to a significant increase in exposure to ticagrelor. Dosage: Acute Coronary Syndromes Treatment with Ticagrelor should start with a loading…

Alcohol and Cardiovascular Disease

…women or five for men on one occasion. Pharmacokinetics and pathophysiology Approximately 95% of ingested ethanol undergoes hepatic metabolism. Alcohol dehydrogenase converts ethanol to acetaldehyde…

Smoking Cessation: Pharmacotherapy and Cardiovascular Benefit

…for smoking and anticipated barriers to cessation. Exposure to second hand smoke. Use of cannabis, electronic cigarettes or other inhaled products. Readiness to attempt cessation…

Anticoagulants: quick reference for dosing, renal adjustment and reversal

…other DOACs are possible according to FASS, but the documentation is insufficient; check more frequently. Warfarin is often preferable <15 or dialysis DOACs are not…

Vulnerable Plaque and Mechanisms of Acute Coronary Occlusion

…demand. In many cases, the initiating process is plaque disruption with thrombosis; other cases result from spasm, microvascular dysfunction, embolism, dissection, hypotension or shock, respiratory…

Physics of myocardial perfusion imaging (SPECT, PET): Radiotracers, perfusion, blood flow and viability

…they annihilate each other, producing two gamma photons emitted in opposite directions. PET scanners detect these gamma rays to construct images with high spatial and…

Cardiovascular Risk in Women: Sex-Specific Factors

…XX and XY individuals and are reflected in cardiovascular structure and function. Sociocultural factors contribute independently to differences in exposure to risk, access to care…

Hypertensive Emergency and Urgency: Differentiation and Treatment

…intoxication, or other sympathomimetic exposure, including methamphetamine. Abrupt withdrawal of antihypertensive medication, particularly clonidine, can also precipitate a hypertensive crisis. Pregnancy Hypertensive emergencies in pre

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