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The Fourth Universal Definition of Myocardial Infarction: Types 1–5

…myocardial injury may accompany numerous cardiac and systemic disorders, including: Cardiac causes Systemic causes Heart failure Sepsis Myocarditis Chronic kidney disease Cardiomyopathy Stroke or subarachnoid…

Primary Aldosteronism: Screening and Management

…and induces expression of aldosterone responsive genes. Although the kidney is a major target—where MR activation promotes sodium transport—MRs are also present in…

Cardiovascular Risk Assessment with SCORE2 and SCORE2-OP

…In apparently healthy individuals, SCORE2 and SCORE2 OP estimates can be used to classify 10 year risk as follows: Risk category 10 year risk of…

Cardiovascular Risk in Women: Sex-Specific Factors

…diseases, including systemic lupus erythematosus and rheumatoid arthritis, are important risk enhancing conditions and are more prevalent in women. Chronic kidney disease and several other…

🟠 Aspirin (Acetylsalicylic acid)

…the efficacy of diuretics and antihypertensives. Risk of acute kidney injury increases when combined with ACE inhibitors. Corticosteroids and other NSAIDs: Increased risk of gastrointestinal…

Assessment of Pacemaker Malfunction

…with the electronics in the pulse generator or dislodgement or fracture of the leads. External causes are less common and include electrolyte disorders, metabolic disorders…

Blood gas interpretation: quick reference for acid-base disorders

…ask which of the pCO₂ and the HCO₃ deviates most. What matters is which change can explain the pH, and whether the other variable lies…

Familial and Genetic Screening in Premature Cardiovascular Disease

…selected congenital heart diseases, pulmonary arterial hypertension and thromboembolic disorders. Most recognised heritable cardiovascular conditions demonstrate autosomal dominant transmission, in which an affected heterozygous individual…

Eletrical alternans: the ECG in pericardial effusion & cardiac tamponade

…local and systemic disorders. Accumulation of fluid in the pericardial space may lead to increased intrapericardial pressure, which in turn affects ventricular relaxation (and thus…

Secondary Hypertension: When and How to Investigate

… rather, it is an indicator of increased cardiovascular risk and a setting in which secondary hypertension is relatively common. Patients presumed to have resistant hypertension…

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