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The Fourth Universal Definition of Myocardial Infarction: Types 1–5

…myocardial injury may accompany numerous cardiac and systemic disorders, including: Cardiac causes Systemic causes Heart failure Sepsis Myocarditis Chronic kidney disease Cardiomyopathy Stroke or subarachnoid…

Primary Aldosteronism: Screening and Management

…which translocates to the nucleus and induces expression of aldosterone responsive genes. Although the kidney is a major target—where MR activation promotes sodium transport…

Cardiovascular Risk Assessment with SCORE2 and SCORE2-OP

…adults with elevated blood pressure (BP), in whom absolute cardiovascular risk varies considerably according to age and the presence of concomitant risk factors. In contrast…

Cardiovascular Risk in Women: Sex-Specific Factors

…reproductive and pregnancy related history. Female specific or female predominant factors associated with later cardiovascular risk include: Premature menopause Premature ovarian insufficiency Hypertensive disorders of…

🟠 Aspirin (Acetylsalicylic acid)

…the efficacy of diuretics and antihypertensives. Risk of acute kidney injury increases when combined with ACE inhibitors. Corticosteroids and other NSAIDs: Increased risk of gastrointestinal…

Assessment of Pacemaker Malfunction

…fracture of the leads. External causes are less common and include electrolyte disorders, metabolic disorders, hypoxemia, antiarrhythmic drugs, or electromagnetic disturbance caused by other machines…

Blood gas interpretation: quick reference for acid-base disorders

…Abnormal A compensated simple disorder, or two opposing primary disorders It is therefore not enough to ask which of the pCO₂ and the HCO₃ deviates…

Familial and Genetic Screening in Premature Cardiovascular Disease

…hypertension and thromboembolic disorders. Most recognised heritable cardiovascular conditions demonstrate autosomal dominant transmission, in which an affected heterozygous individual has a 50% risk of transmitting…

Eletrical alternans: the ECG in pericardial effusion & cardiac tamponade

…and the condition is classified as cardiac tamponade. The classical signs of cardiac tamponade are hypotension, muffled heart sounds and jugular venous distention. Other frequent…

Secondary Hypertension: When and How to Investigate

…Cure is not universal, however. Delayed recognition may permit vascular remodelling and renal impairment to develop, leaving persistent hypertension despite correction of the initiating disorder…

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