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Blood gas interpretation: quick reference for acid-base disorders

…ask which of the pCO₂ and the HCO₃ deviates most. What matters is which change can explain the pH, and whether the other variable lies…

Cardiovascular Risk Assessment with SCORE2 and SCORE2-OP

…particularly relevant in adults with elevated blood pressure (BP), in whom absolute cardiovascular risk varies considerably according to age and the presence of concomitant risk…

Primary Aldosteronism: Screening and Management

…substantial proportion of cases. The cardiorenal and cerebrovascular consequences of unrecognized PA make early case detection clinically important. Current European recommendations advise screening adults with…

Secondary Hypertension: When and How to Investigate

…blood pressure Other cardiovascular risk factors and relevant comorbidities Evidence of hypertension mediated organ damage Existing cardiac, cerebrovascular, or renal disease The possibility of a…

Brugada syndrome: ECG, clinical features and management

…highly malignant disorder that must be recognized by any health care provider. A family history of any of the above listed symptoms and manifestations must…

Peripheral Artery Disease: Diagnosis, Ankle–Brachial Index and Risk Management

…adults over 40 years of age, atherosclerosis is the predominant cause. Other mechanisms include thrombosis, embolism, vasculitis, fibromuscular dysplasia, arterial entrapment, cystic adventitial disease and…

Assessment of Pacemaker Malfunction

…fracture of the leads. External causes are less common and include electrolyte disorders, metabolic disorders, hypoxemia, antiarrhythmic drugs, or electromagnetic disturbance caused by other machines…

The Fourth Universal Definition of Myocardial Infarction: Types 1–5

…because myocardial injury may occur without myocardial ischaemia. Non ischaemic myocardial injury may accompany numerous cardiac and systemic disorders, including: Cardiac causes Systemic causes Heart…

Familial and Genetic Screening in Premature Cardiovascular Disease

…hypertension and thromboembolic disorders. Most recognised heritable cardiovascular conditions demonstrate autosomal dominant transmission, in which an affected heterozygous individual has a 50% risk of transmitting…

Eletrical alternans: the ECG in pericardial effusion & cardiac tamponade

…local and systemic disorders. Accumulation of fluid in the pericardial space may lead to increased intrapericardial pressure, which in turn affects ventricular relaxation (and thus…

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