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Familial and Genetic Screening in Premature Cardiovascular Disease

…Familial and genetic screening in cardiovascular medicine is the systematic assessment of relatives and other individuals who may carry an inherited predisposition to cardiovascular disease…

Familial Hypercholesterolaemia: Diagnosis, Cascade Screening and Treatment

…common inherited metabolic disorder associated with premature cardiovascular disease. Prevalence is higher in populations with a founder effect. HoFH is much rarer, affecting approximately 1…

CME: How dietary fat affects coronary arteries, LDL cholesterol and body weight

…follow. Consider people with the genetic disorder familial hypercholesterolemia (FH), which is caused by genetic mutations affecting the elimination of LDL cholesterol from the blood…

Blood gas interpretation: quick reference for acid-base disorders

…in the same order every time. Skipping a step is a common reason why mixed acid base disorders are missed. The blood gas describes the…

Primary Aldosteronism: Screening and Management

…PA), also termed primary hyperaldosteronism or Conn syndrome, comprises disorders in which aldosterone secretion is inappropriately increased, relatively autonomous from angiotensin II and plasma potassium…

🟠 Aspirin (Acetylsalicylic acid)

…Interactions Pharmacodynamic interactions Anticoagulants, thrombolytics, or other platelet aggregation inhibitors: Salicylates inhibit platelet function and enhance the effect of anticoagulants, increasing bleeding risk. Monitor coagulation…

Chest Pain in the Emergency Department: Diagnostic Pathways

…ACS). Other cardiopulmonary causes , including myopericardial disease, pulmonary embolism, aortic emergencies, and pneumothorax. Non cardiopulmonary causes , including gastrointestinal, musculoskeletal, and anxiety related disorders. The immediate…

Secondary Hypertension: When and How to Investigate

…with particular vigilance when the clinical history includes hypokalaemia. Endocrine disorders account for many secondary forms. Primary hyperaldosteronism is identified as the most frequent cause…

Invasive Coronary Angiography: Indications and Vascular Access

…Although traditionally regarded as an anatomical examination, contemporary ICA can provide complementary functional and structural information. Coronary pressure measurements permit assessment of the physiological significance…

The Fourth Universal Definition of Myocardial Infarction: Types 1–5

…because myocardial injury may occur without myocardial ischaemia. Non ischaemic myocardial injury may accompany numerous cardiac and systemic disorders, including: Cardiac causes Systemic causes Heart…

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