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Approach to patients with chest pain: differential diagnoses, management & ECG

…embolism Mediastinitis (rare condition) In addition to these five conditions, there are numerous other causes of chest pain, but the other causes are either subacute…

Coronary Anomalies and Myocardial Bridging

…in approximately 0.5–12% of angiographic series and up to 5–75% of CT series; other angiographic descriptions report rates of approximately 5–10%…

Familial Hypercholesterolaemia: Diagnosis, Cascade Screening and Treatment

…premature myocardial infarction, vascular disease or marked hypercholesterolaemia. Physical findings related to cholesterol deposition. Untreated or inadequately treated patients may develop premature CAD. Symptoms therefore…

The ST segment: physiology, normal appearance, ST depression & ST elevation

…other conditions that affect the ST T segment and it is fundamental to be able to differentiate these. For this purpose it is wise to…

Chest Pain in the Emergency Department: Diagnostic Pathways

…Myocardial injury leads to release of cardiac troponin, but troponin elevation is not specific for myocardial infarction. Other conditions may produce cardiomyocyte injury and elevated…

Hypertension: Causes, investigations, complications & treatment

…necessary to normalize blood pressure. Management of hypertension requires careful consideration of other cardiovascular risk factors and coexisting conditions. Therapy must be tailored to each…

Acute Coronary Syndrome: Definitions and Initial Triage

…according to the fourth universal definition of MI. Type 1 MI is generally related to an atherothrombotic event, whereas Types 2–5 MI have other…

Resistant Hypertension: Evaluation and Treatment

…treatment related contributors, and excess cardiovascular risk. The European definition requires failure to reduce office systolic and diastolic blood pressure to below 140 mmHg and…

Stent Thrombosis: Timing, Causes, Diagnosis, and Prevention

…length Large thrombotic burdens increase procedural risk because thrombus can fragment, embolize to other coronary branches or vascular beds, propagate through gaps between stent struts…

Type 2 Myocardial Infarction: Mechanisms and Management

…is characterised by myocyte necrosis and troponin elevation due to mechanisms other than myocardial ischaemia. Acute myocardial injury may arise from conditions such as sepsis…

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