…Pharmacology & dosing Definition and pharmacological rationale Bempedoic acid is an oral, small molecule lipid lowering agent used to reduce low density lipoprotein cholesterol (LDL C…

Myocardial ischemia and infarction Pharmacology & dosing Definition and pathophysiology Dual antiplatelet therapy (DAPT) is the combined use of aspirin and an oral P2Y12 receptor inhibitor…

…pharmacological basis Sodium glucose cotransporter 2 (SGLT2) inhibitors are a class of oral agents initially developed for glucose lowering in type 2 diabetes mellitus (T2DM…

…well with oral doses, averaging approximately 0.5 mg/L (0.5 µg/mL) for each 100 mg/day at doses between 100 and 600…

…opposite in each case. Equivalent doses Agent Equivalent glucocorticoid dose Mineralocorticoid effect Biological half life : : : : Hydrocortisone (cortisol) 20 mg Marked Short, 8–12 hours Prednisolone…

…the separate quick reference for dosing in impaired renal function. Respiratory tract Diagnosis Agent Dose Duration : : : : Pneumonia, non severe (DS CRB65 0–1) phenoxymethylpenicillin 1…

…to 25 per cent during the first hour. 2. Thereafter, if the patient is stable, lower the blood pressure towards about 160/100 to 110…

…should as a rule not be lowered rapidly with intravenous drugs. Restart or optimise oral treatment and ensure follow up. Rapid lowering can worsen cerebral…

…common opioids in renal failure Ketobemidone IV 2.5–5 mg Oral bioavailability about 35 per cent Paracetamol PO or IV 1 g × 4 The…