…CKD). These agents interfere with the renin angiotensin aldosterone system (RAAS) by inhibiting the enzyme responsible for the conversion of angiotensin I to angiotensin II…

…Pharmacology & dosing Definition and pharmacological rationale Bempedoic acid is an oral, small molecule lipid lowering agent used to reduce low density lipoprotein cholesterol (LDL C…

…indication for oral anticoagulation (OAC). Clinical context and treatment objectives DAPT is used in two principal settings: After ACS , whether managed medically or with revascularization…

…pharmacological basis Sodium glucose cotransporter 2 (SGLT2) inhibitors are a class of oral agents initially developed for glucose lowering in type 2 diabetes mellitus (T2DM…

…plasma concentrations correlate well with oral doses, averaging approximately 0.5 mg/L (0.5 µg/mL) for each 100 mg/day at doses between…

…ulcer A proton pump inhibitor with concomitant NSAID use or a history of ulcer, not routinely Infection Consider Pneumocystis prophylaxis with high doses over a…

…IV 8 days including oral step down Hospital acquired pneumonia, severe piperacillin–tazobactam 4 g × 4 IV Exacerbation of COPD with an indication for antibiotics…

…with oral drugs under careful observation [3,4]. A markedly raised blood pressure without acute target organ damage should not normally be lowered rapidly with…

…markedly raised blood pressure without acute organ damage should as a rule not be lowered rapidly with intravenous drugs. Restart or optimise oral treatment and…